I think it varies from person to person. Daughter and I both got improved sleep, but I still take meds for sleep. We both got hugely improved cognitive function, but not quite back to 100%. We had flu-like muscle aches pre-Valcyte which is gone now. Neither of us had digestive issues, so can't help you there. Daughter got her energy back and doesn't have PEM. I don't have constant crushing fatigue, but I do get PEM. I wouldn't expect a change in cholesterol to be the result of Valcyte treatment, but who knows? I would say that the biggest changes were in flu-like symptoms -- exhaustion, muscle aches, sore throat, swollen glands, that feeble sick feeling -- and cognitive symptoms. Daughter and I both still need treatment for orthostatic intolerance. That may be permanent -- or just slow to heal -- damage from a neurological hhv-6 infection.