My previous attempts with valcyte using doses on 1 valcyte a day to 1 every second or third dose a day with my normal famvir has left me feeling really bad with fatigue and bad depression from it. During these trials i did have ongoing issues with severe sinusitis which i have sorted now by staying on 200mg doxycycline a day. I have also improved my dhea levels which were well below normal range to within the normal range. I am thinking its more the treating sinuses that has helped me able to tolerate valcyte this time. Also what i am doing is taking the valcyte at night instead of in the morning, so if i am feeling crappy from it i hopefully sleep through it. So far its been about 7 days taking 1 valcyte at night and 250mg of famvir in the morning and other then the first dose with abit of a brain sizzle, i havent had any issues with it. Too early to tell if its helping but i feel like im doing ok. My general stamina has been improving over the last couple of months in reguards to work. I have attempted some light exercise but at this stage it doesnt like me, lol. Cognitive and memory issues dont seem as bad. Its really hard to say if its the things im doing that are helping or im just in an up swing at the moment. Usually when i say im doing well i crash a few days later, so fingers crossed. I have had a few mini crashes but recovered ok from them. I am hoping the valcyte helps me improve to a level of being able to do some light exercise, recovery would be nice but not setting my sights too high yet. Maybe trying to treat other infections first could help people to tolerate valcyte better as well as hormonal issues etc. There have been some people i have read about who had ebv and hhv6 and treated the ebv first with valtrex or famvir and added valcyte later and had minimal issues with valcyte. Also dr lerners study on valcyte did mention that little improvement in people with co-infection unless co-infections were treated, so i think the sinusitis is my co-infection i had to sort first. cheers!!!