I tried it for a while to help me sleep better. Made me sleepy at night, though not any more rested in the mornings. It also made me really extra moody, though (weepy, etc.). I'm an odd case, though (aren't we all? ). I responded terribly or strangely to regular antidepressants too, so I figure there's got to be something up with my serotonin processing or something. Like everything, I think it's all a bit of trial and error to see what works with your chemistry. My husband's using 5-htp for his sleep, and it's been FANTASTIC for him. He doesn't have ME, though. Low serotonin seems to have been his sleep issue in the first place.