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Trouble with tribbles: orexin, sleep and wakefulness, narcolepsy, autoantibodies

Discussion in 'Other Health News and Research' started by WillowJ, Mar 11, 2015.

  1. WillowJ

    WillowJ คภภเє ɠรค๓թєl

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    http://www.medicalnewstoday.com/articles/290623.php

    They think the antibodies are autoimmune.
     
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  2. WillowJ

    WillowJ คภภเє ɠรค๓թєl

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    This might be the medical journal article:

    http://www.journalsleep.org/ViewAbstract.aspx?pid=27838

    Anti-Tribbles Homolog 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy
    Minae Kawashima, PhD1; Ling Lin, MD, PhD1; Susumu Tanaka, PhD2; Poul Jennum MD, Dr. Med. Sci.3; Stine Knudsen, MD, PhD3; Sona Nevsimalova, MD4; Giuseppe Plazzi, MD5; Emmanuel Mignot, MD, PhD1


    1Center for Narcolepsy, Stanford University School of Medicine, Palo Alto, CA; 2The Sleep Disorders Research Project, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan; 3Danish Center for Sleep Medicine, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark; 4Department of Neurology, Charles University in Prague, 1st Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic; 5Sleep Disorders Center, Department of Neurological Sciences, University of Bologna, Bologna, Italy



    The full text appears to be free, but I cannot read it just now.

    It relates to us because it's said that many PWME and PWfibro have narcolepsy.

    It's also said that we have sleep wave intrusions during wake times, and wakeful wave intrusions during sleep. So maybe this sort of thing is going on?
     
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  3. WillowJ

    WillowJ คภภเє ɠรค๓թєl

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    I actually found the study the article was referring to and it's a different one. Which is actually cool. Here's that:

    http://www.sciencedirect.com/science/article/pii/S1043661814001662


    Is narcolepsy a classical autoimmune disease?
    • a Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel
    • b Center for Autoimmune Diseases Research – CREA, Universidad del Rosario, Bogota, Colombia
    • c Doctoral Program in Biomedical Sciences, Universidad del Rosario, Bogota, Colombia
    • d Rheumatic Disease Unit, Sheba Medical Center, Tel-Hashomer, Israel
    • e The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2013, Sheba Medical Center, Tel-Hashomer, Israel
    • f Sackler Faculty of Medicine, Tel-Aviv University, Israel
    • g Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Tel Aviv University, Israel

    This one costs $35.95
     
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  4. alex3619

    alex3619 Senior Member

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    I have something resembling narcolepsy from time to time. I can stay awake but the concentration of doing that means I am incapacitated. I cannot even read or watch a movie. So the only thing to do is go to bed. Its not like narcolepsy in movies, I don't just nod off, but there is serious compulsion to sleep.

    There is more to this than just orexin. I am not sure there is only one type of narcolepsy.
     
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  5. August59

    August59 Daughters High School Graduation

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    Every neurologist and sleep specialist I've seen considers narcolepsy to be an autoimmune disease.

    Antibodies destroy hypocretins (orexin??). If cataplexy accompanies the narcolepsy then there is high probability that HLA variant is present.

    http://med.stanford.edu/news/all-ne...immune-disorder-stanford-researcher-says.html

    I'm like Alex as I can have episodes of moderate to severe narcolepsy, then go 6 months without any problems at all. I just happen to be in an episode when i had the MSLT (nap test). On one "nap" I had sleep latency of 9 seconds and was in REM stage in 45 seconds.

    Over the last 6 months I can't fall asleep if I'm outside of my circadian rhythm which has my sleep period from 5am till 10am. From 10am till 1pm I'm in a can't sleep, but can't wake up stage. This pretty much falls directly i line with my cortisol levels by way of 4x saliva test (on 2 separate occasions.)
     
  6. WillowJ

    WillowJ คภภเє ɠรค๓թєl

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    I have similar symptoms from time to time.

    It looked like the Kawashima paper noted the existence of subgroups, but I was not able to properly read it.
     
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  7. WillowJ

    WillowJ คภภเє ɠรค๓թєl

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    Interestingly enough, the Stanford group also found an association with some biomarker and recent onset:

     
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  8. August59

    August59 Daughters High School Graduation

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