Daffodil
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trial: Gut Flora in MS
- Thread starter Daffodil
- Start date
Interesting - is anyone doing this in ME - i.e. comparing gut flora between PWME and healthy people?
beaverfury
beaverfury
- Messages
- 503
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- West Australia
http://clinicaltrials.partners.org/trials.aspx?tId=5232
Healthy Children ages 4 to 18 years are needed for a research study at Massachusetts General Hospital looking at the intestines (gut) in multiple sclerosis
What are we studying?
• The digestive system (i.e. stomach, intestines, etc.) and the normal bacteria called flora found in the gut
• We want to see if there are differences in the normal flora between children who have multiple sclerosis and those that don’t
- A Comparison of the Predominant Gut Flora in Patients with Relapsing- Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis and Healthy Adults
Healthy Children ages 4 to 18 years are needed for a research study at Massachusetts General Hospital looking at the intestines (gut) in multiple sclerosis
What are we studying?
• The digestive system (i.e. stomach, intestines, etc.) and the normal bacteria called flora found in the gut
• We want to see if there are differences in the normal flora between children who have multiple sclerosis and those that don’t
Glynis Steele
Senior Member
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- 404
- Location
- Newcastle upon Tyne UK
Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome.
Sheedy JR, Wettenhall RE, Scanlon D, Gooley PR, Lewis DP, McGregor N, Stapleton DI, Butt HL, DE Meirleir KL.
Source
Bio21 Institute of Biotechnology and Molecular Science, Department of Biochemistry and Molecular Biology, Victoria, Australia.
Abstract
Patients with chronic fatigue syndrome (CFS) are affected by symptoms of cognitive dysfunction and neurological impairment, the cause of which has yet to be elucidated. However, these symptoms are strikingly similar to those of patients presented with D-lactic acidosis. A significant increase of Gram positive facultative anaerobic faecal microorganisms in 108 CFS patients as compared to 177 control subjects (p<0.01) is presented in this report. The viable count of D-lactic acid producing Enterococcus and Streptococcus spp. in the faecal samples from the CFS group (3.5 x 10(7) cfu/L and 9.8 x 10(7) cfu/L respectively) were significantly higher than those for the control group (5.0 x 10(6) cfu/L and 8.9 x 10(4) cfu/L respectively). Analysis of exometabolic profiles of Enterococcus faecalis and Streptococcus sanguinis, representatives of Enterococcus and Streptococcus spp. respectively, by NMR and HPLC showed that these organisms produced significantly more lactic acid (p<0.01) from (13)C-labeled glucose, than the Gram negative Escherichia coli. Further, both E. faecalis and S. sanguinis secrete more D-lactic acid than E. coli. This study suggests a probable link between intestinal colonization of Gram positive facultative anaerobic D-lactic acid bacteria and symptom expressions in a subgroup of patients with CFS. Given the fact that this might explain not only neurocognitive dysfunction in CFS patients but also mitochondrial dysfunction, these findings may have important clinical implications.
PMID:
19567398
[PubMed - indexed for MEDLINE]
Free full text
This study is now being followed up with this one:
http://sacfs.asn.au/download/Lactic acid study 2008 - Ethics Application.pdf