Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Treatment of Primary Sjögren Syndrome With Rituximab: A Randomized Trial

Discussion in 'Other Health News and Research' started by Bob, Feb 24, 2014.

  1. Bob

    Bob

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    A recently published French clinical trial of Rituximab for Sjögren Syndrome patients.
    There was not a significant outcome in this trial when assessed at six months.

    Treatment of Primary Sjögren Syndrome With Rituximab:A Randomized Trial
    Valérie Devauchelle-Pensec, MD, PhD; Xavier Mariette, MD, PhD; Sandrine Jousse-Joulin, MD; Jean-Marie Berthelot, MD; Aleth Perdriger, MD, PhD; Xavier Puéchal, MD, PhD; Véronique Le Guern, MD, PhD; Jean Sibilia, MD, PhD; Jacques-Eric Gottenberg, MD, PhD; Laurent Chiche, MD, PhD; Eric Hachulla, MD, PhD; Pierre Yves Hatron, MD; Vincent Goeb, MD, PhD; Gilles Hayem, MD; Jacques Morel, MD, PhD; Charles Zarnitsky, MD; Jean Jacques Dubost, MD; Jacques Olivier Pers, MD, PhD; Emmanuel Nowak, PhD; and Alain Saraux, MD, PhD
    Ann Intern Med. 2014;160(4):233-242-242.
    18 February 2014
    http://annals.org/article.aspx?articleid=1829791


    Here's a couple of articles that explain the results:
    http://www.2minutemedicine.com/rituximab-not-be-beneficial-long-term-in-sjorgens-syndrome/
    http://www.medpagetoday.com/Rheumatology/GeneralRheumatology/44363

    "The results of this study suggest that rituximab (Rituxin) treatment is not associated with a significant improvement in symptoms or disease activity at 6 months for patients with primary Sjogren syndrome (pSS)."

    "There were transient improvements in fatigue symptoms at 6 weeks, but the benefits were no longer significant at 6 months."
     
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  2. user9876

    user9876 Senior Member

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    I'm not sure you would expect an improvement at 6 months given treatment was weeks 0 and 2. Rituximab will wipe out b-cells and hence eventually antibodies but they come back without repeated treatment.
     
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  3. Bob

    Bob

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    Good point. I can't remember the time scale that B cells are expected to be replenished.
     

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