Intro and TLDR: I would really appreciate any help. My brainfog is so bad, I can't function at all. My intelligence is draining and my ability to do simple tasks is fading. Although Mfolate + MB12 etc helped me initially with dopamine, It sparked horrible inflammation and autoimmune nerve issues (twitching, tingling etc) . So I thought it best to tackle methylation later. My plan was to lower inflammation and toxin/pathogen burden by starting with GI, parasites and yeast, move to broad spectrum anti pathogen like banderol etc while doing detox…then get on an anti inflammatory and start methylation. However, I noticed yasko discusses treating SHMT first in order to alleviate gut issues, but the treatment involves folinic acid. Will this also whip up inflammation and exacerbate my autoimmune issues like mfolate, mb12 etc? What about taking HB12 to help with sulfur and NO without taking mfolate? Why did methylation treatment exacerbate my autoimmune disease? How can I avert that and what is the best way to proceed with methylation side of things? Any insights on my other SNPs? Thanks! In depth Background, details and SNPs: SNPS: A link to the full MTHFR support report with immune, detox, methylation etc is here:https://docs.google.com/spreadsheet/pub?key=0Ajm4ylAWb_FkdGl0aTEtN0pMX2NvdGVmMUtRWmx1Vmc&output=html Just a list of my methylation SNPs is below: Heterozygous risk: ACE Del16 AHCY-01 AHCY-02 AHCY-19 BHMT-04 BHMT-08 CBS A13637G CBS C699T MTHFD1 C105T MTHFD1L MTR A2756G MTRR rs10520873 MTRR rs162049 MTRR rs3776467 PEMT SHMT1 C1420T SHMT1 SHMT2 TCN2 C766G TYMS VDR Taq A whole bunch of GAD Homozygous Risk: COMT H62H COMT V158M DHFR MTHFR C677T MTHFS NOS2 NOS3 NOS3 NOS3 T786C PEMT SLC19A1 SLC19A1 VDR Bsm Urine AA: On a 3 year old 24 hour urine AA my Taurine was 1700 on a 195 - 1400 ref range and my ammonia was 54 on a 10-50 ref range. Cysteine, gaba and sarcosin also high. Also Glutamine/glutamate ratio was high, but the ref range only had a low number( 9 and mine was 26). Current symptoms: I’m 24 I have some unspecified autoimmune disease resulting in periods of neuropathy and fasciculation’s that get better and worse, but in general trending towards worse. Also affects muscle strength. Cognitive functioning as well, both from a memory perspective, but also from an energy/mitochondria perspective because if I think too much or try to use my PFC, my brain basically shuts down and I get foggy and spacy , if I try to push through, it gets worse. A bit Better if I eat or have some coconut oil. Started to get derealization. Also get little non blanching dots on my skin. Doctors can’t put it in a b Definitely feel, sound and am getting dumber the longer this goes on :/ History of illness: I was born with some delayed speech and non verbal/spatial learning issues. I;v always had executive functioning and anhedonia/low dopamine pfc problems, . Never really been able to put on weight, but its getting worse with the autoimmune stuff. Trigger and patterns: Although I have always had issues, the worse fatigue and the autoimmune neuropathy symptoms started 2 years ago when I tried to fix methylation defects. Taking 5 mthf and ramping up methylation cycle was helpful by increasing dopamine, helping social anxiety and executive functioning , but set off inflammation as it often does with people with autoimmune disease. Response to supplements: Many supplements trigger exacerbations of my autoimmune issues. This includes supplements that help in other ways such as zinc. Even anti inflammatories such as boswelia, Kalawalla and fish oil either make me sick by triggering infection , or increase the neuropathy and hair loss (perhaps they increase pathogen proliferation or reduce the wrong kind of cytokines?). Takes me months to recover partially mentally and physically from a flare Did not do well increasing vit d intake. PQQ and d-ribose helps with mental energy and PFC functioning Magnesium helps with anxiety, but I think I am sensitive to it. Also on oregano for general anti pathogen. Progesterone and adrenal cortex extract also help. Other more upstream issues are methylation snps, gut issues (unknown yeast and unknown parasite, but flora ok), autoimmune tendency (mom has sjogren, grandmother behchets) , possibly HHV6 and mercury heavy metal poisoning (borderline high on hair test). May have other intracelluluar pathogen nothing confirmed, vit d 25 oh and 1.25 ratio out of whack, low vit d. I have mild classical ehllers danlos syndrome and my brain is very sensitive to blows or any quick turns of the neck. I have constant low level congestion in right sinus, get frequent throat (strep + and - ) and sinus infections. Had tonsils out for this, barely helped. Labs show borderline low white count that I have had forever, Positive ANA 1/125 with speckled pattern, low vit d3 , high-ish urine ammonia, the gut issues I mentioned (stool test), zinc and niacin deficiency on spectracel, tanked adrenals. No overt lesions on brain MRI, borderline high RT3. Lyme Igenx is not overtly positive. Doctor said it was negative. Thanks!