Discussion in 'Genetic Testing and SNPs' started by minkeygirl, Aug 28, 2013.
Not me, Minks, not me. I know nuttin'.
No idea - all I know is that CBS C699T, and the CBS gene in general, are pretty well excluded from causing sulfur problems
I'm 3.3% Neanderthal
Us Neanderthals have to stick together!
I know it could be SUOX, but I am guessing there's more to it.
I guess Valentijn settled it: It's a good thing. Hugs to my neanderthal relatives:
Critterina, Is there different post that shows how you figured out that the CBS mutations don't cause a 10X upregulation? Or can you direct me somewhere else?
There sure is, and I wish I could find it. A bunch of people on this forum read the research and discussed it. I have looked a few times and couldn't find it. I have considered asking a moderator to help me find it again, but haven't got to it yet. If you do that, please post a link to that post here. I'll bookmark it next time.
It's in the methylation subforum, which is why I can never find it It's really an SNP thread though, so I'll ask to have it moved over here.
That is good news. (CBS C699T +/+) I eat tons of sulfur foods with little problems and most low sulfur foods would kill me- grains, seeds beans- no can do! Give me some cabbage, onions and garlic!!! Where did you hear this @Valentijn?
It's in the published research regarding that specific SNP.
I read this whole thread and I am afraid I see some confusion and incorrect statements.
Without knowing your other SNPs in the methylation pathway, any recommendation on how to treat a CBS mutation is ill advised.
Whether or not a CBS mutation will cause over-sulfuration will also depend on other SNPs, like MTHFR, BHMT, and MTR/MTRR. The combination of mutations will cause varying levels of sulfur and homocystine.
I have homozygous CBS C699T (+/+). I HAD terrible sulfite and sulfur sensitivities because I also am Homozygous MTHFR A1298C and homozygous MTRR A66G AND homozygous BHMT-08. YIKES! I was not turning my homocystine back into methionine and so a lot of homocystine was being funnelled quickly down my transulfuration pathway.
When I started taking B12 and 5-MTHF I would get symptoms like I ate too much sulphites. When I add PLP (pyridoxine 5 phosphate) and Molybdenum those symptoms vanish.
I can now eat high sulphur foods and have no rhinitis, brain fog, or fatigue.
To say that a homozygous CBS mutation does not matter cannot be substantiated at this time.
In my own N=1 experiment, it matters tremendously.
A homozygous CBS mutation could be a good thing because, if homocystine is damaging to the body (the science is still out, but I think any imbalance leads to health issues), this mutation turns the homocystine into something less harmful.
A CBS +/+ mutation might also use up a lot of Serine.
Fascinating! What are your high sulphite symptoms? I just got my genes back (see below) and trying to learn how this CBS mutation affects MTHFR.
The rhinitis (nasal swelling with no mucus) is the strongest and quickest sign for me that I am overdoing my transulphuration pathway. Weirdly enough it usually only effects my left sinus, my cortisol symptoms can raise a bit as well giving me heart palpitations. Later on I get the fatigue and my mood gets a bit aggressive and depressive.
You really can't depend on my symptoms though, watch yourself after eating high sulphur foods. Also, MAO and COMT mutations could change how transulphuration pathway excess is expressed from my understanding. (mood disorders)
That is what I don't get... how does CBS interact with my +/+ MAO A and other stuff? Going to doc in two weeks- hopefully get some answers then.
Because I don't notice a big deal with just high sulphur foods- just about all foods cause me inflammation. If it is sulphur, what to do? Some sulfur foods have too many health benefits to give up like cruciferous and garlic. So can I take yucca and charcoal or something to counteract this? The reason I ask is because most LOW sulphur foods like grains and beans are EXTREMELY detrimental to me so if I eliminate too much there would be nothing left for me to eat!
Also, what about high ammonia? Not to be gross, but I have had that from time to time strong ammonia during menses accompanied by worsening... flooring actually, chronic fatigue, nausea, feeling sick. Years ago I was convinced I had porphyria because of constipation, sun sensitivity and ammonia smell. But my urine was never purple. I tried citrulline malate and thought I had found my cure until I got these scary panic attacks where my mind and heart would not stop racing and had to stop.
So I know ammonia could be a problem. Is this related to CBS?
yes, CBS has everything to do with ammonia:
First, the term "Sulphur Rich Foods" is thrown around a lot without understanding of what it means and I do the same, unfortunately, only because it is not so clear to me yet as it is only a recent focus. It is more complicated than people give credit. You need to know what form of sulphur you have an issue with. This is for another day. Just do not worry about sulphur so much, focus on fixing the pathway.
So we see if someone's CBS and SUOX are homozygous we have a back up the the middle there. So you have more ammonia and more coritsol. With more cortisol (stress) you release more nor-epinephrine (fight or flight). If you have a COMT mutation you have norepinephrine staying around too long and all the flight and fight that goes along with that.
I have no idea why you took citruline for ammonia, I guess to push the urea cycle. My own opinion: I think the biggest mistake to make is to supplement with amino acids. I see amino acids as bricks and enzymes as workers. To build a building faster you don't add more bricks, you add more workers, unless you do not have enough bricks. Bricks are easy to get and they do not complain as much as workers.
So I think it might have to do with your SUOX gene. Maybe. Do you know if you have any mutations there?
If you do not know what your SUOX mutations are, log into 23andme and click the following link, let m know what you see: https://www.23andme.com/you/explorer/gene/?gene_name=SUOX
I am pretty sure my SUOX is normal.
According to genetic genie I have no suox mutations. Here is what the link you posted told me on 23andme:
SUOX56391486rs705703C or T
SUOX56397916i5000977A or C
SUOX56397941i6028286C or T
SUOX56398711i5000976A or G
I'm guessing that means no mutations?
This was years ago before 23andme and before I knew about CFS. I thought I had porphyria (I don't but was desperate for an answer to health problems). I was trying to reduce ammonia. Also took methionine but not sure if that helped or not. Very interested what you think to take if not bricks/aminos.
Yeah, I think that means no mutations. So this is interesting. More later when I look at some things.
Thiols in the diet will use up SAMe, and if you do not have enough SAMe you will suffer more from the Thiols. If our methylation pathway is messed up = less SAMe = higher thiol sensitivity.
Low S-adenosylmethionine concentrations found in patients with severe inflammatory bowel disease.
Methionine derivatives diminish sulphide damage to colonocytes--implications for ulcerative colitis.
@Adlyfrost , Do you have gut issues like I do? Bloating, etc?
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