Sam-e seemed to be great for my brain fog and focus/concentration http://www.ebrainsupplements.com/best-of-nootropics-same I have terrible brain fog and exhaustion from sleep apnea and heard that TBI brain injury treatments work for that. I did have profound effects from sam-E so I'm taking methylfolate and vitamin B I'm curious how methylation seems to work to cure brain fog and give clarity/concentration. it seems to induce hormonal changes and give me cystic acne but then I am still foggy today? today I'm really foggy and can't focus even on 800mg of sam-E, will try 800mg more. do glutamine, alpha gpc, phos choline, theanine help brain fog?