Professor & patients' paper on the solvable biological challenge of ME/CFS: reader-friendly version
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Treating Acidosis with Erythromycin

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by SB_1108, Apr 3, 2017.

  1. SB_1108

    SB_1108 Senior Member

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    Just wondering if anyone knew of any medical studies about treating acidosis with erythromycin?

    KDM is my doctor and he recently suggested it for elevated lactic acid issues.
    Dr. Sarah Myhill also suggests it for acidosis:
    http://www.drmyhill.co.uk/wiki/Ferm...nd_CFS#Treatment_of_high_Streptococcus_levels

    I've also found this article about treating ME/CFS patients with erythromycin to reduce lactate producing bacteria (like Strep) and improve sleep: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688574/

    Anything else?

    I thought that penicillin was the first choice for lactic acid producing bacteria?
     
    Last edited: Apr 3, 2017
    Valentijn likes this.
  2. kangaSue

    kangaSue Senior Member

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    Is the source of acidosis definitely bacterial? Acidosis can also be caused by ischemia (hypoxia) in which case antibiotics are not likely to be effective.
     
    AkeBono likes this.
  3. SB_1108

    SB_1108 Senior Member

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    Not sure? How do you tell them apart?

    My acidosis symptoms began after antibiotics and it is worsened by carbs and certain probiotics. Major digestive correlation!
     
  4. kangaSue

    kangaSue Senior Member

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    Good question, I'm not sure of the answer though. Pain is the usual reaction to hypoxia and L-lactate might be elevated in the blood (the liver is usually very efficient at mopping it up) but pain is the result of a lot of other insults other than ischemia.

    Are you going on symptoms alone or have you tested to elevated lactate levels? People with ME/CFS can have elevated levels of either L-lactate or D-lactate, the latter able to cause brain fog to and some people get elevated levels of D-lactate from eating carbs.

    SIBO from taking antibiotics can cause similar symptoms without elevating lactate levels.
     
  5. outdamnspot

    outdamnspot Senior Member

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    what are the symptoms you associate with acidosis?
     
  6. SB_1108

    SB_1108 Senior Member

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    I can't have any carbs at all - no potatoes, bread, nuts, fruit, etc - because I begin to experience acidosis symptoms pretty severely. I become completely exhausted, unable to move or speak, gasping for air - feeling like I'm dying because I can't get enough oxygen. Even my daily cup of coffee has become a problem. My food allergies in general are completely out of control. I think gut fermentation is a huge part of this problem. I'm down to eating about the same five foods on rotation.

    My gastroenterologist wanted me to try Amoxicillin so for the last three days I did that... it hasn't been good. I won't be taking it tomorrow.
     
  7. SB_1108

    SB_1108 Senior Member

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    Yes I'm going off symptoms alone. I have been diagnosed with SIBO.
    Have any suggestions? :(
     
    ljimbo423 likes this.
  8. kangaSue

    kangaSue Senior Member

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    Maybe get tested for elevated levels of D-lactate. Some people with ME/CFS find that carbs produce elevated levels of D-lactate, the same situation can occur with Short Bowel Syndrome which is a malabsorption problem.

    My GI motility specialist said to me to assume that you have SIBO too in anyone having chronic delayed motility problems and suggested rotating between different antibiotics for 10 days every month for 6 - 12 months (amoxycillin, doxycycline and metronidazole). I'm hard pressed to tolerate them for five days.

    Rifixamin is often suggested for SIBO but studies don't find it any better than the combo of standard antibiotics. I have seen it suggested by several people that combining rifixamin with metronidazole was effective when rifixamin alone didn't help with symptoms.
     

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