I have been sick for almost a decade. And I have this strange reaction I'd like your opinions on. When I begin on various antibiotic cures - I improve greatly for some days - and then I slip back. This has happened with minocycline, ceftriaxone, clarithroymcin, ciprofloxacin and other antibiotics. Now this is what happens; I begin on the antibiotic, it goes a day or two, and suddenly I feel better. Much better. It lasts for some days, before it fades away. Here are my thoughts on why this happens: Hypothesis 1) All of those antibiotics have immunomodulatory effects. I have tests displaying a immune system out of balance. When the antibiotics are given, this modulates itself in the right direction, and I improve. There's a reason why the immune system is out of balance. It might be the virus keeping it out of balance, or it might be the body which tries to fight a virus, and therefore is 'overactive' (and thereby out of balance). Whatever reason for the unbalance, either if it's a virus causing it, or the body responding to a active virus. It adjusts itself back, after I modulate it with drugs. So if the drugs get the immune system under control for some days, then the body will adjust it back, because the body feels "it needs to keep it that way, because of the infection". And when that happens - I feel worse again. Hypothesis 2) What happens when I get the antibiotics is that the antibiotics themselves fight off unwanted bacteria in the colon/gut. Those bacteria causes immune dysfunction, so when the bacteria are fought, the immune system gets better. This only works for some days, and then I slip back. There are some things which point away from hypothesis two, and that is that I can't think of a reason for why the treatment would only work for some days. If it was because of bacteria fighting effects in the colon/gut, it should continue to work when I continue to take it. And if it's resistance (which I doubt can happen in just days) then I find it strange that the same antibiotic works again the next time I take it (if there is some time since last time I took it). And -- several antibiotics have made me feel significantly better within the same day as I begun taking it (penicillin G and ceftriaxone). The same day. That is also something which points away from hypothesis two. The only thing I can think of - which happens the very first days as a antibiotic is taken, is that as soon as it's up in the blood stream, it begins modulating the immune system. This is true for many antibiotics. Clarithromycin's direct effects on the cytokine balance. Ciprofloxacin's direct effects on the cytokine balance. There are many others, I could look them up, but it proves the point. Most antibiotics do have direct effects on the immune system (not going via antimicrobal activity). So, I'd appreciate your thoughts on this. Am I onto something?