TPH1 TPH2 anyone research as related to use of anti-depressants?

[roxie60]

Appears to be some research regarding these genes and effectiveness of various anti-depressants. Just wondering if anyone had already gone down this rabbit hole and found anything useful like finding SNPs/alleles that would make various antidepressants more or less effective. I am aware the CYP genes also play a role in effectiveness of anti-depressants.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044192/

 

[roxie60]

the reason I ask is years ago (late 1980's, early 1990's) I was put on Prozac to treat depression. It appeared to really make a difference (I called it my happy pill) but only lasted about 10 months and then I crashed, became serverly depressed, lethargic. I had been given a multitude of SSRIs for many years after but none had any affect or made things worse. I stopped taking SSRIs for last 10-13 years, did not see a reason to keep trying. Then in 2006 I was put on Cymbalta for depression/anxiety and pain even tho I reported not being depressed (an SNRI - affects serotonin and norepinephrine and the side affects of that one were frightening, became so ill and dysfunctional). To this day a Cymbalta commercial comes on tv and I have to change the channel, I use to yell and scream first but I have move past that reaction to the commercials. Just always wondered what happened, Prozac was effective for short period of time, then crash (side effects almost as if I had stopped taking the drug even tho I was taking it since it had been helping), then not affective.

an SNRI, which means that it not only blocks serotonin reuptake but also norepinepherine(adrenaline).