the reason I ask is years ago (late 1980's, early 1990's) I was put on Prozac to treat depression. It appeared to really make a difference (I called it my happy pill) but only lasted about 10 months and then I crashed, became serverly depressed, lethargic. I had been given a multitude of SSRIs for many years after but none had any affect or made things worse. I stopped taking SSRIs for last 10-13 years, did not see a reason to keep trying. Then in 2006 I was put on Cymbalta for depression/anxiety and pain even tho I reported not being depressed (an SNRI - affects serotonin and norepinephrine and the side affects of that one were frightening, became so ill and dysfunctional). To this day a Cymbalta commercial comes on tv and I have to change the channel, I use to yell and scream first but I have move past that reaction
to the commercials. Just always wondered what happened, Prozac was effective for short period of time, then crash (side effects almost as if I had stopped taking the drug even tho I was taking it since it had been helping), then not affective.
an SNRI, which means that it not only blocks serotonin reuptake but also norepinepherine(adrenaline).