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TPH1 TPH2 anyone research as related to use of anti-depressants?

Discussion in 'Genetic Testing and SNPs' started by roxie60, Aug 3, 2013.

  1. roxie60

    roxie60 Senior Member

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    Central Illinois, USA
    Appears to be some research regarding these genes and effectiveness of various anti-depressants. Just wondering if anyone had already gone down this rabbit hole and found anything useful like finding SNPs/alleles that would make various antidepressants more or less effective. I am aware the CYP genes also play a role in effectiveness of anti-depressants.

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044192/
     
  2. roxie60

    roxie60 Senior Member

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    the reason I ask is years ago (late 1980's, early 1990's) I was put on Prozac to treat depression. It appeared to really make a difference (I called it my happy pill) but only lasted about 10 months and then I crashed, became serverly depressed, lethargic. I had been given a multitude of SSRIs for many years after but none had any affect or made things worse. I stopped taking SSRIs for last 10-13 years, did not see a reason to keep trying. Then in 2006 I was put on Cymbalta for depression/anxiety and pain even tho I reported not being depressed (an SNRI - affects serotonin and norepinephrine and the side affects of that one were frightening, became so ill and dysfunctional). To this day a Cymbalta commercial comes on tv and I have to change the channel, I use to yell and scream first but I have move past that reaction ;) to the commercials. Just always wondered what happened, Prozac was effective for short period of time, then crash (side effects almost as if I had stopped taking the drug even tho I was taking it since it had been helping), then not affective.

    an SNRI, which means that it not only blocks serotonin reuptake but also norepinepherine(adrenaline).
     

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