pattismith
Senior Member
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This thread is most of all to remind and warn about mito toxicity of Doxycycline and Azythromycin.
Many recent studies talk about their ability to target the cancer cells because of this property that inhibit cell multiplication (they inhibit bacteria multiplication as well).
An interesting thing I learnt in it is that N Acetyl Cystein partially reverses this inhibition (so we can wonder if NAC may inhibit the antibiotic effect as well!)
Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467100/
Induction of Mitochondrial Dysfunction and Oxidative Damage by Antibiotic Drug Doxycycline Enhances the Responsiveness of Glioblastoma to Chemotherapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584825/
Azithromycin effectively inhibits tumor angiogenesis by suppressing vascular endothelial growth factor receptor 2-mediated signaling pathways in lung cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494938/
Many recent studies talk about their ability to target the cancer cells because of this property that inhibit cell multiplication (they inhibit bacteria multiplication as well).
An interesting thing I learnt in it is that N Acetyl Cystein partially reverses this inhibition (so we can wonder if NAC may inhibit the antibiotic effect as well!)
Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467100/
Induction of Mitochondrial Dysfunction and Oxidative Damage by Antibiotic Drug Doxycycline Enhances the Responsiveness of Glioblastoma to Chemotherapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584825/
Azithromycin effectively inhibits tumor angiogenesis by suppressing vascular endothelial growth factor receptor 2-mediated signaling pathways in lung cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494938/