lostinthedesert 1. What have your melanocyte stimulating hormone (MSH) and vasoactive intestinal peptide (VIP) readings been like over time? I'm interested in having people talk about that on this board b/c I think we'll find that a fair number of us have high C4a, high TGF-Beta 1 and low VIP and MSH. 2. One other thing re: cholestyramine (CSM). Unfortunately no one has ever done any research to determine what it's binding and expelling from the body. It most certainly could be toxins, but my understanding (and someone please correct me if I'm wrong) is that CSM and similar meds like Welchol could be binding and removing inflammatory byproducts from our bodies. This seems plausible to me. People with these abnormal biomarkers are "caught" in a chronic inflammatory state and something that removed some of the inflammotary byproducts in our bodies could theoretically help. Like I said, we actually know what exactly CSM and Welchol do, but it is very clear that they help a number of people.