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Topical cathelicidin (LL-37) an innate immune peptide induces acute olfactory epithelium inflammatio

Discussion in 'Mast Cell Disorders/Mastocytosis' started by osisposis, Jul 25, 2016.

  1. osisposis

    osisposis Senior Member

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    Cathelicidin (LL-37) is an endogenous innate immune peptide that is elevated in patients with chronic rhinosinusitis (CRS). The role of LL-37 in olfactory epithelium (OE) inflammation remains unknown. We hypothesized that: (1) LL-37 topically delivered would elicit profound OE inflammation; and (2) LL-37 induced inflammation is associated with increased infiltration of neutrophils and mast cells.

    LL-37 has dramatic inflammatory effects in the OE mucosa that is dose-dependent. The observed inflammatory changes in the olfactory mucosa were associated with the infiltration of both neutrophils and mast cells. Our biologic model represents a new model to further investigate the role of LL-37 in OE inflammation.

    http://www.ncbi.nlm.nih.gov/pubmed/26346056
     

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