Here's the (kind of) quick version: I started methylation about 5 months ago (early May) and I've had some ups and downs. I started on 1mg MB12, and 1 tablet of Thorne B-12 Complex. Some mild energy gains but nothing major. But, in mid-July, I slowly started adding in ADB12 (Source Naturals Dibencozide). This is where it gets interesting: within hours of my first mini-dose, I got red, itchy spots on my cuticles. I thought maybe this was my immune system coming back online, and thus a good sign. But maybe a week later, as I upped the dosage to around 2mg/day, I got what I thought was food poisoning (so bad I spent around 4 days running to the toilet), followed by a cold with lots of coughing and mucus that lasted about 2 weeks. I haven't upped my MB12 above 1mg/day, mainly because of concerns the late Rich Van Konynenburg raised about mercury. But I wanted to keep pushing forward, so in early August I upped the ADB12 to one full tablet (9mg) every other day, and actually cut down the MB12 to every few days. Added in 400mcg of folate as well. I felt great at first, good enough to actually go to the gym for the first time in years, pushed myself, and crashed. I was exhausted and could barely stay awake - pushed myself again a few weeks later and have spent most of the last two months really tired. In late September, I caught another cold and am still coughing up a lot of mucus. Some other weird symptoms (excessive sweating, dizziness, heart palpitations) have popped up as well. The last few days have been quite good, but I'm still a bit uncomfortable with what's going on. Is this detox, or folate deficiency? Am I taking too much ADB12? Not enough folate? Not enough MB12? --------------------------------------------------- EXTRA INFO: So, these are the symptoms I've had since starting methylation, all of them really just since I upped the ADB12 and lowered MB12: Rashes/itchy red spots on fingers, arms, back Diarrhea Fatigue Muscle cramps Sore throat and cough Swollen lymph nodes under armpits Significantly worse BO Feeling hot/sweaty (I got a massage and I was soaked afterwards) Heart palpitations Some dizziness (an old symptom) But of course, I have to note that there have been moments of incredible energy as well. My methylation stack is currently this: 1mg B12 Infusion 1 capsule Thorne B Complex #12 400 mcg Solgar metafolin 4-4.5mg Source Naturals Dibencozide (ADB12) per day (one 9mg tablet every 2 days) I also take a multivitamin that does contain 400mcg of folic acid, adrenal glanduar, pantethine, Vit C, Glutamine, Zinc carnosine, pharmacy bought cal/mag supp, and maca root. --------------------------------------------- Basically, I need to find a way to safely proceed without these ups and downs. I just started a serious relationship, I'm going to be moving multiple times in the coming months and I just can't have these kinds of fluctuations. My baseline was very good - more than good enough for me to have an active and fulfilling life sans exercise. I didn't notice much at first with MB12, but once I upped the ADB12 I did feel really supercharged for a bit, and at times still do. But I want to feel at least as good as I did before on a consistent basis, and not like I'm on a roller coaster. Sorry for the wordiness. Thanks in advance for any input!