Like many here, I’m seemingly always fighting a rearguard battle against deficiencies & toxicities. As for the deficiencies: I usually improve when I top up iron, zinc, vitamin D and the Bs, chromium, and some amino acids. As for the toxicities: I also usually improve when I rotate my diet, and chelate out heavy metals, and eat less carbs & sugars, and top up endocrine hormones, and feed my gut good bacteria. This applies, at least. when the Freddd Protocol dosages are right. A complicating factor is that, after a spectacular start, the improvements usually fade after a few days or a few weeks. I’ll assume for now that over time my dosages somehow become sub-optimal. That’s a problem I’m working on. Ramping folate higher & faster is the present tactic. But the fact is that, for so long as it is working, the FP provides many of the gains I have been seeking via the above long list of ad hoc measures. My need for many of the listed items diminishes: almost immediately, I can drop hydrocortisone doses, & get away with eating more carbs. I can chelate much more comfortably (a massive thiol reaction from stirring up mercury on taking ALA was ended when I began m-folate). Energy is better, without the need to supplement vitamins & minerals quite so obsessively. Why is that, in your humble opinion?