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TNF-alpha inhibitor for Alzheimer's disease

Discussion in 'Other Health News and Research' started by natasa778, Jan 5, 2015.

  1. natasa778

    natasa778 Senior Member

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    Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease

    Recent clinical studies point to rapid and sustained clinical, cognitive, and behavioral improvement in both Alzheimer's disease and primary progressive aphasia following weekly perispinal administration of etanercept, a TNF-alpha inhibitor that acts by blocking the binding of this cytokine to its receptors. This outcome is concordant with recent basic science studies suggesting that TNF-alpha functions in vivo as a gliotransmitter that regulates synaptic function in the brain. We hypothesized that perispinal etanercept had the potential to improve verbal function in Alzheimer's disease, so we included several standarized measures of verbal ability to evaluate language skills in a clinical trial of perispinal etanercept for Alzheimer's disease.

    ... This was a prospective, single-center, open-label, pilot study, in which 12 patients with mild-to-severe Alzheimer's disease were administered etanercept, 25–50 mg, weekly by perispinal administration for six months. Two additional case studies are presented.
     
  2. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    Czechosherlockia, USA
    That's Tobinick in Florida.

    2008
    Keynote: Repurposing of Enbrel® for Alzheimer

    Note that Etanecept (not perispinal) for CFS was halted for harm:
    Tumor Necrosis Factor-alpha Inhibition Using Etanercept in Chronic Fatigue Syndrome
    This study has been terminated.
    (After inclusion of four patients, two experienced moderate worsening of symptoms)
    Haukeland University Hospital
    https://clinicaltrials.gov/ct2/show/NCT01730495?term=etanercept cfs&rank=1
     
    NK17 and natasa778 like this.

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