I am up to 16mg of methylfolate a day, 650mg l-carnitine fumarate, 30mg methylb12, and 10mg adb12 a day right now. I do have some improved mental energy but it is not as significant as I had hoped for. Could I be missing something? Should I try adding Sam-e or TMG? Which should I try first? And, what are some other factors which can inhibit methylation?