The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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TLR-2 and borrellia (lyme)

Discussion in 'Lyme Disease and Co-Infections' started by roxie60, Oct 25, 2014.

  1. roxie60

    roxie60 Senior Member

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    Central Illinois, USA
  2. duncan

    duncan Senior Member

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    I would interpret it the same way. I notice the publication date is 2005. It is also primarily a German endeavor, and that country hasn't been as quick as others to wholeheartedly adhere to IDSA Guidelines.

    I wonder if there were ever any follow-up studies.

    Incidentally, you would think the NIH would be following this lead, or even something similar, considering its principal, if not sole, focus these days is diagnostics.
     
    Last edited: Oct 26, 2014
  3. Valentijn

    Valentijn Senior Member

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  4. duncan

    duncan Senior Member

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    rsID? Boy, do I feel ignorant... This is gene talk? I can almost guarantee the NIH isn't looking at this relative to Lyme patients. :)
     
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  5. Valentijn

    Valentijn Senior Member

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    It's been researched a fair bit regarding other infections, and it sounds like variations elsewhere in the gene often have a very significant impact.

    23andMe data for the rest of the gene looks very normal for 31 patients I have full data for, when compared to 31 controls. One possible exception is rs3804100 where we have 2 patients and 0 controls who are homozygous for the rare version. The usual homozygous prevalence is 1.2%, but we're at 6.5%. It could just be a fluke though, since it's pretty small sample size.
     
  6. duncan

    duncan Senior Member

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    "23andMe data for the rest...looks very normal for 31 patients..." Lyme patients?
     
  7. Valentijn

    Valentijn Senior Member

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    ME patients from this forum.
     
  8. duncan

    duncan Senior Member

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    Understood. Thanks.
     

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