Hi guys, I have come off effexor, and this time - instead of a 1 month then feeling like shit, its taken about 3 months. I think ive found SAM-e treatment useful, and im also going the zinc/b6 route. But im getting the full lethargy symptoms again. I was on 150mgs of effexor I'm now on 500mgs each l-methionine and tmg. and 75mgs b6/zinc 25mgs 5htp 100mg before bed. (occasionally - might need more frequently?) My dreaming has improved - i seem to wake up from dreams with heart racing, so i'd say sleep may have a major impact on whats going on, also not sleeping for near as long. As far as the effexor helping keep levels of serotonin/norepinephrine - does anyone know how i might tweak whats going on to mimic what effexor did for me, without taking it? On effexor i have a zombie mind state, off it i have a body tiredness state.