Hi, I am having real difficulties getting to the bottom of my methylation problems and have not been able to find a doctor anywhere (in the UK) who knows anything much about epigenetics or methylation issues (tried Sarah Myhill but she isnt taking patients anymore). The Yasko methylation test revealed the following mutations: - CBS A360A++ - MTRR A66G++ - MAO A/R297R++ And a host of other more minor mutations (incl. BHMT (1,2,4, 8) +/-, VDR Taq1 & Fok1 +/-) My Genova Metabolic Analysis revealed deficiencies in B12, folic acid, B2 and B6 (the last one was wierd because a recent blood test suggested my B6 levels are high!). I have tried taking the above vitamins and the B6 and B2 broke my skin out (a common reaction in me) and the folic acid made me feel very down and depressed I have tried so many things to detox in the past but i react very badly and often suffer from skin outbreaks. Despite what some say on this forum, i think the CBS mutation is a problem for me. I have had plenty of allergic reactions to sulphates and medication in the past although dont have too many problems with eggs and broccoli. From all the reading i have done, i think i am definitely an over methylator although my homocysteine levels have never been checked! I have just ordered a hair and mineral test to check my sulphur and lithium levels, but am really wondering whether i have to spend yet more money on getting my amino acids tested to get to the bottom of all of this! Am curious to know if anyone has had any success with dealing with the CBS mutation using the Yasko supplements? PS. I forgot to mention that I also react badly to Vit D, essential fatty acids....always break out in acne with these things!