here's a question to those who've been dealing with it a while and hopefully have a bit of the science details familiarized: What is it that exactly causes people to have mast cells more prone to degranulation or hyper activation? I mean is there anything that stands out in particular as being guilty of causing this sort of immune balance? I also find it interesting that while some people have really overt mast cell conditions like asthma or as the histamine chef talked about 'projectile vomiting after exercise' 'or getting sick on a plane', other people like me seem to just have really intense chronic fatigue that comes with histamine causing foods and stress in general. I also think that arguably some people who have Rheumatoid arthritis probably have a bit of this going on. I have noticed a lot of RA people seem to really respond well to a vegan diet. ..(it would be much lower histamine generally). I notice that people with fully developed ME/CFS often have mast cell issues. So it seems something escalates the imbalance. What I partly blame for this at least in a rudimentary way, are arachidonic acid + low omega 3 + not enough resolution in inflammation, i.e., chronic inflammation, mast cells will release tons of leukotrine and prostaglandin and for some *reasons* the body doesn't have enough of the omega 3 end products (resolvins, protectins) and anti-inflammatory arichidonic acid end products (lipoxins). As for omega 3's I know they help. I mean I know that's one of the giant causes- too much omega 6. I use to eat 30 fish pills during flair ups several years ago. ..but I didn't know that's what it was at the time. It was just something I figured out. I've found some interesting articles, and even a chinese formula that is noted to affect this particular immune imbalance. Someone also mentioned to me that they take a thymus glandular, cytosol extract, as well as bone and kidney. Also unsurprisingly Cannabis is one of the only things that seems to actually promote resolution of inflammation in the literature (I can't find anything else that does) as opposed to just blocking it out with NSAIDS. (TL;DR cannabis enhances lipoxins which do the opposite of the leukotrines that things like berberine or ursolic acid, tea, luteolin, quercitin block (LOX inhibitors). Blocking luekotrines vs. increasing lipoxins). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464915/ This formula + Reishi. http://www.americandragon.com/Herb Formulas copy/WuMeiWan.html https://en.wikipedia.org/wiki/List_of_therapeutic_monoclonal_antibodies http://www.itmonline.org/arts/lox.htm But certainly more and more, I'm leaning towards water fasting. Total avoidance of food intolerances are about the only thing that ever helped. At least, for me it was a pesco-vegetarian diet that allowed me to originally recover for a while before I chelated incorrectly. I had simply 'accidentally' discovered a low histamine diet.