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This Week in Virology on Lipkin/Hornig CFS study

Discussion in 'Latest ME/CFS Research' started by Esther12, Mar 22, 2015.

  1. Esther12

    Esther12 Senior Member

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    http://www.twiv.tv/2015/03/22/twiv-329/

    They mention:

    -need to compare CFS patients to ill-health controls rather than healthy controls, in case this is a marker for generalised ill health/strain/similar.

    -likelihood of subgroups and need to try to identify them.

    -wonder how people's cytokine patterns vary over time?

    Go on to mention the poor Lancet editorial on IOM/SEID and talks about PACE and Cochrane claiming unblinded trials show that patients should try exercising (no real engagement with this - think that they may have assumed that this was trustworthy).

    Sounded like Vincent's son could have something CFS-like - hope not/get well soon!
     
    Last edited: Mar 22, 2015
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  2. Dolphin

    Dolphin Senior Member

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    Vincent was (and may still is?) part of the CAA/SMCI scientific and research advisory board/similar so maybe that was why they could get him to take on such (voluntary) work?
     
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  3. Esther12

    Esther12 Senior Member

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    It sounded like he was no longer on their advisory board, and that maybe that pre-dated his son's illness?
     
  4. Dolphin

    Dolphin Senior Member

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    Ok, my guess could be wrong then.
     
  5. Simon

    Simon

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    Thanks. It's worth noting that the summary of the paper (from the person who asked the panel to discuss this) wasn't quite right in one regard: the paper itself doesn't claim biomarkers (though there was some hype along those lines in the press release). When I spoke to Dr Mady Hornig she was well aware they need to do more work to prove a biomarker, which includes replication and comparing with sick controls, not just healthies: she said they are keen to do this and just need the funds...
    It's a great point - there is no data on how cytokines fluctuate over time in healthy people.

    Columbia (Mady Hornig and co) already have a study underway with 50 patients (I think) where they go back one year on to see if cytokines chance in individuals the way their study predicts. For some patients they have data at three time points, each a year apart. So that should help show if the findings in the recent cross-sectional study actually pan out for individual patients over time.
     
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  6. aimossy

    aimossy Senior Member

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    They also noted that Michael (insert last name) paper from Stanford @Simon the genetics guy? The researcher who followed his own system for 14months or something. Watched what his system did when sick with illness.
     
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  7. Simon

    Simon

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  8. aimossy

    aimossy Senior Member

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    This Stanford study interested Professor Warren Tate in New Zealand with respect to ME/CFS research.
     
    Last edited: Mar 23, 2015
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  9. Gemini

    Gemini Senior Member

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    Dr. Snyder's self-study is on-going, 3+years. Vincent was incorrect when he said it lasted 1 year.

    Interestingly it has been expanded to track cytokines, the autoantibody-ome, & microbiome among other things.

    He's tracking molecular pathways activated during the host's response to infection. He's experienced 4 to date, one triggered his genetic predisposition to diabetes.

    Last Fall Dr. Snyder gave this one-hour review of "Genetics & Medicine." An update of his study starts at 28:35:

     
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  10. Ecoclimber

    Ecoclimber Senior Member

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    March 22, 2015

    [​IMG]


    http://traffic.libsyn.com/twiv/TWiV329.mp3


    Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

    The TWiV team reviews identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection.



    Click arrow to play
    Download TWiV 329 (79 MB .mp3, 110 min)
    Subscribe (free): iTunes, RSS, email

    Links for this episode
    Timestamps by Jennifer. Thank you!

    Vincent Racaniello states that his son and believes that it could be ME/CFS. His wife is a psychiatrist who is trying to find the reason for the illness.....interesting.
     
    Last edited: Mar 26, 2015
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  11. barbc56

    barbc56 Senior Member

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    August59 likes this.
  12. Ecoclimber

    Ecoclimber Senior Member

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    Ok, I did a search on the title and came up empty so mods can delete this duplicate thread.Thx
     
  13. barbc56

    barbc56 Senior Member

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    Been there. Done that!

    Barb
     
  14. Gemini

    Gemini Senior Member

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    Esther12 likes this.
  15. Simon

    Simon

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