I think I've hit major donut hole deficiency. I've been on 3-4000mcg a day of methylcobalamin and 800mcg divided methylfolate for approx a month. Now I feel I'm stuck or going backward. Body just feels really swollen. When I add any adeno (even the tiniest amount) I have a huge added need for more methylofolate. I have read and try and understand the titration. I should up my methylfolate a lot? Take 3-4 of 800mcg ---and then what do I do? Do I drop back down to maybe 1000mcg daily (up it a little each day) or continue to take the 3-4 800mcg daily? If anyone can explain, please help. You guys are amazing at helping!!