I was reading the Thiamine Deficiency thread over in general treatment and got to wondering about it. I'm on an ever-increasing L-5 methyl-folate treatment, along with dozens of other supplements including methyl-B12 sublinguals, P-5-P, etc. I was seeing very significant improvements for about two months, and then started to slightly backslide. Another increase in L-5 MTHF; helped initially. I'm coming off a rough week though and was thinking about seeing if maybe all this increasing the one B vitamin might be causing inbalance issues and if Folate and Thiamine are competitors - it might be worth adding Thiamine to my routine. Does anyone know of any issues with 'type' of Thiamine to take when factoring in methylation issues? I'm asking because I'm pretty darn sure that when I blindly followed doctors orders to take Folic Acid, B6, and B12 is what actually started my health decline. Now that I know that forms of B vitamins matter to us with methylation issues - I won't EVER just throw a B vitamin into my diet without a little digging first. I haven't found anything in any of the recommendations I'm seeing on various sights.... mthfr.net, heartfixer, yasko, etc. But head fuzziness could be interfering.