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The Undetectable Infection

alex3619

Senior Member
Messages
13,810
Location
Logan, Queensland, Australia
@Elph68Quite a few people who caught my virus also developed IBS.

Almost everyone gets Herpes viruses or Enteroviruses, so for a long time the idea was discredited, which is why the idea of pathogenic colonies of what superficially might appear to be normal bacterial species were also discredited.

Yet newer data does appear to support an enteroviral causation, and once these viruses are in play the gut will be modified, which may alter the gut bacteria anyway. The widespread pervasiveness of enteroviral infection in us, including that we appear to be the only group having anything like 83% prevalence of enteroviruses in the gut wall make this a dominant hypothesis for me.

However there may be subgroups. It also cannot be ruled out that multiple factors might make us vulnerable to enteroviruses.

In my case I am positive for Coxsackie B3 by antibody, though I have not had a gut biopsy to look for ongoing infection.
 

globalpilot

Senior Member
Messages
626
Location
Ontario
Almost everyone gets Herpes viruses or Enteroviruses, so for a long time the idea was discredited, which is why the idea of pathogenic colonies of what superficially might appear to be normal bacterial species were also discredited.

Yet newer data does appear to support an enteroviral causation, and once these viruses are in play the gut will be modified, which may alter the gut bacteria anyway. The widespread pervasiveness of enteroviral infection in us, including that we appear to be the only group having anything like 83% prevalence of enteroviruses in the gut wall make this a dominant hypothesis for me.

However there may be subgroups. It also cannot be ruled out that multiple factors might make us vulnerable to enteroviruses.

In my case I am positive for Coxsackie B3 by antibody, though I have not had a gut biopsy to look for ongoing infection.

Exactly my thoughts. I posted a study earlier showing a particular virus in the lungs increased substantially bacterial colononization.

Just sent my 2nd biopsy in to Dr Chia and eagerly awaiting my results.
 

Hip

Senior Member
Messages
17,820
Almost everyone gets Herpes viruses or Enteroviruses, so for a long time the idea was discredited.

I know that many researchers say that since most people who catch herpes family viruses and enteroviruses and remain healthy, these viruses cannot be the cause of ME/CFS. But that argument is complete nonsense.

If you look at poliovirus, for example: when poliovirus was still in circulation, most people catching this virus would show no symptoms at all, and remain totally health and unaffected by it. However, a tiny percentage of people would develop poliomyelitis after catching poliovirus — sometimes with fatal consequences.

Thus the idea that because a virus causes no symptoms in most people, it therefore cannot cause some disease in a minority of individuals is a totally incorrect idea, as the poliovirus case demonstrates. I cannot understand how any researcher can even suggest such an idea.
 

Hip

Senior Member
Messages
17,820
I should point out that it is very easy, just using simple logic, to prove that herpes family viruses such as HHV-6 and EBV cannot be the triggering viruses of ME/CFS. This logic is as follows:

You can exclude herpes family viruses from being the precipitating infectious cause of ME/CFS simply by the fact that (a) ME/CFS most frequently develops in adults, (b) nearly all adults will already have HHV-6 and EBV in their body, since HHV-6 is usually picked up before you are 3 years old, and EBV is picked up usually in the teenage years. Ergo, when you observe that you have caught some virus that then precipitated your ME/CFS, it is very unlikely to ever be HHV-6 and EBV, since the majority of adults already have these two viruses in their body already.

I am not sure why ME/CFS researchers have overlooked this basic fact, which generally rules out HHV-6 and EBV as being the triggering viruses of ME/CFS. Of course, HHV-6 and EBV already in your body may be reactivated by the immunosuppression of ME/CFS, and may then contribute to ME/CFS symptoms, sure, that is another story. So it is still a good idea to take anti-herpes drugs. But HHV-6 and EBV cannot be the triggering virus of ME/CFS that you catch as a adult, in the general case at least).

Enteroviruses such as coxsackievirus B and echovirus are a different story, because although one or two of these may be caught early in life, there are in fact 6 serotypes of coxsackievirus B (not to mention the various sub-strains of each serotype), and there are 32 echovirus serotypes, so you can certainly catch a nasty enterovirus later in life as an adult, even if you caught one as a child.
 

alex3619

Senior Member
Messages
13,810
Location
Logan, Queensland, Australia
Yes, I agree Hip that common pathogens that everyone gets can indeed be a cause, yet the CDC was pushing this for a very long time if I recall correctly. It also ignores what we know of immune response - how respond may alter the outcome. In some diseases there is a discreet difference in outcome based on patient response. I think Leishmania is one.

Herpes virus cannot be ruled out for similar reasons that enteroviruses cannot be ruled out. These viruses lurk, and the damage may be a result of widespread neurological infection, and that takes time. Then something comes along and triggers the disorder. However I find the Herpes virus argument much less compelling than the enteroviral one.

I do agree that most Herpes infections do not make sense as a triggering virus.
 

heapsreal

iherb 10% discount code OPA989,
Messages
10,086
Location
australia (brisbane)
I know that many researchers say that since most people who catch herpes family viruses and enteroviruses and remain healthy, these viruses cannot be the cause of ME/CFS. But that argument is complete nonsense.

If you look at poliovirus, for example: when poliovirus was still in circulation, most people catching this virus would show no symptoms at all, and remain totally health and unaffected by it. However, a tiny percentage of people would develop poliomyelitis after catching poliovirus — sometimes with fatal consequences.

Thus the idea that because a virus causes no symptoms in most people, it therefore cannot cause some disease in a minority of individuals is a totally incorrect idea, as the poliovirus case demonstrates. I cannot understand how any researcher can even suggest such an idea.

I think this is why the cfs gurus are now looking more into the immune syste. Can't remember who said it but they use to call cfs The Bug of the Month. So many different infections were implicated but they couldn't nail it down to one cause.

I think it was dr Nicholson who said the longer one is sick with cfs the more infections they find.

Many cfsers can remember the onset of cfs, maybe this initial infection is what has 'broken' the immune system, which then leaves us open to other infections. The immune dysfunction especially nk function seems to be the most common finding more so then anyone infection.

Hopefully in the next 12months we have more answers from researchers. Promising thing is we seem to have more researchers than we have had in a long time.
 

heapsreal

iherb 10% discount code OPA989,
Messages
10,086
Location
australia (brisbane)
It's not impossible for ebv cmv hhv6 to be the initial trigger, maybe more common then your indicating. I say this as the dubbo studies followed people (adults)after glandular fever infections as well as other viruses. It was about 10% who ended up with ongoing fatigue. Cmv mono that was apart of my cfs onset at the age of 31. Again I think it's a sub group thing and whenever cfs is researched there's always this ebv group that pop up. Dr Peterson has mentioned that this herpes sub group are the group that they can potentially improve or maybe cure as there's treatments available.

We are just all unique with infections and immune issues but all have cfs me. When they eventually work this mess out, I think we are all going to need different treatments. It would make it easier if there was just one universal cause:)
 

Elph68

Senior Member
Messages
598
[qu
I think this is why the cfs gurus are now looking more into the immune syste. Can't remember who said it but they use to call cfs The Bug of the Month. So many different infections were implicated but they couldn't nail it down to one cause.

I think it was dr Nicholson who said the longer one is sick with cfs the more infections they find.

Many cfsers can remember the onset of cfs, maybe this initial infection is what has 'broken' the immune system, which then leaves us open to other infections. The immune dysfunction especially nk function seems to be the most common finding more so then anyone infection.

Hopefully in the next 12months we have more answers from researchers. Promising thing is we seem to have more researchers than we have had in a long time.

So the next question is then ..... who can emphatically tell me they don't have strep in their gut??
 

MeSci

ME/CFS since 1995; activity level 6?
Messages
8,231
Location
Cornwall, UK
Sexual transmitted infection?? Now you are accusing my husband to have pissed outside the pot. Or do you mean I did? Or do you mean my mother gave it to me in the womb, during birth or breast feeding?

Please expain why I have improved very much without taking any antibiotics.

and why the monoclonal antibody rituximab produces remission in a good proportion of sufferers.

I am bemused that you think that you know better than numerous eminent scientists, and better than the scientists among us who have read, and evaluated, and made connections between many many scientific findings.

I'm not saying that your theory is wrong, just that your level of certainty appears excessive.
 

MeSci

ME/CFS since 1995; activity level 6?
Messages
8,231
Location
Cornwall, UK
CFS The undetectable infection: The symbiotic relationship.

I may as well get laughed off this forum, as every doctor I have spoken to has thrown me out of my office when I present them with the argument of pathogenic normal flora!

Normally we are colonized with numerous bacteria and viruses which are both good and bad. These live in a slurry on the surface of our mucous membranes, mouth nose, throat, vagina, urinary tract, colon etc. A symbiotic relationship develops and many of these organisms are able to attach onto cell receptors so they can permanently inhabit the mucous membranes. When they live on the mucous membranes in this manner the body is protected from any virulence traits of the organism, and the organism is protected from being attacked by the bodies immune system. And in this manner, the body and organism get something from this relationship.

When an organism is pathogenic it has acquired the ability to breech the epithelial layer of the mucous membrane and then has access to the underlying cells and blood stream. This is the point where the body's immune system comes into play and it launches an attack against the invaders. All of you who have been studying the immune system can tell me more about the chemistry of the immune system but basically there are pro inflammatory enzymes (cytokines) released (this is why there is inflammation) the bodies attacking force arrives at the site of inflammation and starts fighting the invaders, and then there is an anti-inflammatory enzyme released which then turns off the inflammation. Until the invaders are destroyed, this is a continuous process. So if you are one of the 25% of people that have an interleukin 10 deficiency, you would have continuous visible inflammation. Most people who have normal interleukin 10 have inflammation initially, and then it goes away but the battle still goes on. As a result of the battle you have this cocktail of inflammatory and anti inflammatory enzymes (cytokines), dead invaders, antibodies and expressed proteins and enzymes from the invaders circulating through your blood stream. Basically we are being continuously poisoned from the battle. I reckon this alone makes us really sick ...

A bacterial pathogen has one purpose, attack at the cellular level, create pus and thus create an environment that is good for them. Viridans streptococcus however works more like guerrilla warfare. It is happy with its symbiotic relationship but also likes to launch invasive attacks, and as they are non pyogenic (don't form pus) all as you have is an inflammation. Scientists know that viridans strep species can cause infection if it is allowed to enter the bloodstream (bacteremia) scientists haven't caught on yet that some strains of viridans streptococcus and enterococcus have found the ability to breach the epithelial layer and live at the cellular level.

(I believe this is why so much time has been spent looking for viruses because there is no pus, just inflammation!!)

If I was a researcher and wanted to look at any one bug, I would start with streptococcus sanguinis/parasanguinis and I will explain why next ......

I have never heard cytokines being called enzymes before.

I certainly subscribe to the theory of compromised biological barriers allowing pathogens access to the bloodstream and hence the whole body. My own preferred theory is that this leads to autoimmunity, as described in this paper.

Microorganisms are well-known to mutate, so the theory of symbionts becoming pathogenic is plausible. However, I believe that it is more normal for microorganisms to become less pathogenic or non-pathogenic after inhabiting a living body for some time, unless perhaps there is gene transfer to them from a pathogen. It is not in their interests to start causing damage to their hosts after living in harmony for so long, as it could reduce their own chances of survival.

Is gene transfer part of your theorised mechanism?
 

MeSci

ME/CFS since 1995; activity level 6?
Messages
8,231
Location
Cornwall, UK
I reckon there are under 18's here .... I am not going to put up some of the tests I have done in an open forum.

But this should be classed as an STI ....

I can't think what might be unsuitable for under-18s to read about a medical issue, considering what else they can view on the internet!
 

MeSci

ME/CFS since 1995; activity level 6?
Messages
8,231
Location
Cornwall, UK
this is exactly why I didn't want to open that can ..... any one of what you quote is likely and possible but I will also add, kissing, antibiotic use, sharing food and drinks, visiting the dentist .....

In that case I would not call it an STI, but an infection transmissible between people.