Me again Freddd, sorry! I didn't hear from you following my last post, so I just had a go at changing something to see if anything would change. All I did was divide the folate dosage, keeping the total amount (800mcg/d) unchanged, and double the bedtime potassium to 2g. Well, possibly coincidentally, for the following 2 weeks, Anna was on what looked like a major recovery path - she was getting all sorts of unaccustomed sensations like those little fingertip pains - and quite a lot of her symptoms were improving noticeably. But then a week ago, that stopped - both the unaccustomed sensations and the improvement in symptoms, and she's sinking back to her prior state. Any ideas? Does the body become somehow used to the regime, and stop responding, so that it's necessary to increase amounts of some things over time, to maintain the effect? If so, which things? Trial and error? Which ones most likely? She's still taking only 1 x B12 Infusion and 0.5 x Dibencoplex - should we try increasing one or both? Or the LCF (currently 1x 855mg)?