Alex from here used a shot gun approach a few years ago and had some success, but used a few different supps, i think from memory and had some side effects. I dont think this is really going to cost too much when buying from iherb, maybe abit of an initial outlay but most supps will last 2-3 months , approx $30 a month maybe, under estimate. I will already be using other supps and most of us taking a heap and i already take some of this and many overlap with what im trying to accomplish. Here goes a big list, sort of break it down to mito/methylation/antioxidant: MITO- ribose/creatine, q10, acetly l carnitine, NAD, magnesium MEHTYLATION BLOCK(bascis)- methyl b12, methylfolate. ANTIOXIDANTS- NAC, vit E, Vit C, Alpha lipoic acid. Now im not going to take them all at once but slowly add them every few days and judge the effects. I suppose i will rattle when i walk too. I will still be using antivirals, sleep meds and a few other things. Now there are a few cfs/me studies showing increased oxidative stress, low glutathione levels, low q10 and carnitine. These sort of tests here in australia are dam expensive, it would be nice to be able get these pre and post 'shot gun' but money only gos so far. In another post i have mentioned i have used most of these supps in some way but not to this extent. Im also in a different state of improved health sinse then with lower viral load, sinuses sort of controlled and healthy dhea levels. I would appreciate anyone elses experience with doing shot gun approach similar to this and also if they had testing done before and after and noticed lab improvements and symptom improvements. It might be awhile before i really get started with this but will try and keep updates going when i can. I have gone from a lerner scale of a 3 out of 10 to a 6-7 out of 10 with antivirals/immune/infectious treatments but can drop down with a crappy sleep pattern or PEM etc, you know how it is. SO what im trying to achieve is a 9 or a 10 level. At the moment my symptoms are ok if i do little out side my full time work but if i go outside that im knackered. I know many would just like to work fulltime and im greatful for that but its still not a life and u dont know how long u can maintain this either, always on the lookout for a crash. As of now on all the antioxidants, AL Carnitine, q10. appreciate any feedback, cheers!!!