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The saga of XMRV: a virus that infects human cells but is not a human virus

Discussion in 'XMRV Research and Replication Studies' started by Bob, Apr 15, 2014.

  1. Bob

    Bob

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    The saga of XMRV: a virus that infects human cells but is not a human virus
    Maribel Arias and Hung Fan
    Cancer Research Institute and Department of Molecular Biology and Biochemistry, University of California
    Published online 9 April 2014
    Emerging Microbes & Infections (2014) 3, e; doi:10.1038/emi.2014.25

    http://www.nature.com/emi/journal/v3/n4/full/emi201425a.html

    Full article available.
  2. Bob

    Bob

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    The above quote from the abstract is incorrect. Paprotka et al. later rebutted their own recombination paper, and we don't know how XMRV was created.
    Valentijn likes this.
  3. barbc56

    barbc56 Senior Member

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    Does it make a difference if the origin of xmrv is different? If it does, what impact would this have on Lipkin's study?

    Barb
  4. Bob

    Bob

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    Personally, I think we know very little about XMRV at this stage. Obviously, it can infect human tissue, and it has infected human tissue in the lab. That's about all we know. XMRV could have been created in the cell-line, as has been proposed, but the original evidence for that hypothesis was somewhat flawed. If I remember correctly, it was shown that XMRV might have evolved in the cell line, and so this means that there is still a possibility that it was created from the recombination of two alternative viruses (other than pre-XMRV1 and pre-XMRV2.) Alternatively, XMRV could have entered the cell line via external contamination. This possibility hasn't been explored very much, as far as I'm aware. I'm not sure how widespread XMRV contamination is thought to be in other cell lines, but I think there have been papers published about it.

    I don't think any of this affects Lipkin's study, because he has pretty much shut down that line of research.
    I'm not sure of the exact details, but the suggestion is that he found similar quantities of retrovirus in patients and control samples, in his latest study.
    Perhaps if he found it in different quantities then he might have pursued it further, seeing as he's a virus hunter. But there again, maybe he thinks its too controversial.
  5. Aerose91

    Aerose91 Senior Member

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    Can someone fill me in on the story about xmrv? I heard recently that it was disproven and is not a factor at all
  6. Esther12

    Esther12 Senior Member

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    That's a pretty good summary.

    Could go into more detail, but there's currently no good reason to think XMRV is related to CFS.
  7. Aerose91

    Aerose91 Senior Member

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    Thank you I've been flip-flopping on it. Is xmrv even a real virus?
  8. Esther12

    Esther12 Senior Member

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    Errr... depends what you mean by 'real virus' I think. It's thought that the positive samples were a result of contamination, and that XMRV is not circulating in the human population. Overall: not something that's worth investigating unless you have an academic interest in viruses imo.
  9. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    @Aerose91

    If I have it right, xmrv is a real virus but was accidentally created in the lab? So basically a lab contaminant. :confused:

    Sushi
  10. Aerose91

    Aerose91 Senior Member

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    Wow, thats brutal. Glad we don't have to worry about it!

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