Could mercury poisoning be a key issue in ME/CFS or other diseases? It certainly has neuro-immune consequences. A book published last October might be worth looking at - Diagnosis: Mercury: Money, Politics, and Poison by Jane M. Hightower, M.D. I just learned of it and have not read it, but it might be useful in understanding some of the system dysfunctions other than the glutathione cycle that may be effected. Since Dr. Hightower has treated patients it might be useful in detox treatments. It seems that any test for mercury is rather complex, that a number of processes can cause poor excretion of mercury, glutathione being only one. Poor excretors will test low to no level of mercury in blood, urine, or hair. Stimulation of excretion by chelating will not tell you how much body burden you have, only that you do have it, nor will it tell you were it is concentrated. Individual organs can be building up mercury, requiring biopsy to find the level. Heart biopsy has found level 22,000 times normal. There is an apparent affinity between virus particles and mercury. Is this another chicken and egg problem in ME/CFS? Do we have unknown toxic body burdens of mercury? Could transport and deposition of viral particles in the body be facilitated by mercury?