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The role of Adaptive and Innate immune cells in Chronic Fatigue Syndrome/Myalgic Enchephalomyelitis

Discussion in 'Latest ME/CFS Research' started by aimossy, Dec 19, 2013.

  1. SOC

    SOC Moderator and Senior Member

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    Makes us freakin' miserable. ;)
  2. alex3619

    alex3619 Senior Member

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    Too much blood in some places, not enough in others, we are like jigsaw people if this is right.
    aimossy and SOC like this.
  3. Sea

    Sea Senior Member

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    I was part of this study and have been sick 27 years, so I think they just mean at least 2 years
  4. alex3619

    alex3619 Senior Member

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    Thanks Sea, nice to have that clarified. Even if it was an average just one person sick 27 years would push it way up I would have thought.
  5. aimossy

    aimossy Senior Member

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    its not bad research eh!:)
    whats next?
    more depth with a bit of expansion with this and a higher cohort number........progress i feel.merry xmas everyone....no wonder we feel like shit!
    :Dim on my phone in a paddock i hope prof jonathan edwards has some comments.phone is difficult so i hope some kind person links this to his thread.:)
  6. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    Here's his thread:

    http://forums.phoenixrising.me/inde...tatement-on-uk-rituximab-trial-30-july.24499/

    That's as kind as I can manage! :D
    aimossy likes this.
  7. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    Very helpful summary, thanks!

    I wonder whether blood clotting is another issue where there are subgroups? My own erythrocyte sedimentation rate (ESR) has tested normal, and my blood seems to flow normally when I have a cut.

    I have recently been getting to grips with some genetic test results from years ago, which I had filed away, and I have a variation in eNOS3 (endothelial nitric oxide synthase 3) that reduces platelet activity.
    alex3619 likes this.
  8. alex3619

    alex3619 Senior Member

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    Its more a propensity for blood clotting, to clot still requires secondary factors, and hence there will be some variability.
  9. Firestormm

    Firestormm Senior Member

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    Thanks for the summary Alex and for your thoughts. Can you explain why you think (or the authors think) this profile is consistent with autoimmune disease - what they or you are comparing it to - please? Thanks
    aimossy likes this.
  10. alex3619

    alex3619 Senior Member

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    Hi @Firestormm, that was their statement if I recall correctly. Elevated Tregs are, I think, associated with autoimmune diseases. However its possible this is not always true. Elevated Tregs may suppress NK cells too, though I am not sure that is well correlated with autoimmune diseases, I have never heard of that.

    That would be a good question to ask Brenu etc.
    aimossy and Firestormm like this.
  11. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    Just found that ESR is more about inflammation than blood clotting - need to refresh my memory before posting! :redface:
  12. alex3619

    alex3619 Senior Member

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    I commented on blood clotting largely due to elevated platelet count. Under conditions where clotting might occur this might induce increased clotting. It still requires a trigger though. Elevated platelets are a known risk factor for thrombosis.
    aimossy likes this.
  13. Forebearance

    Forebearance Senior Member

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    Thank you so much for your summary, Alex!
    alex3619 likes this.
  14. Ema

    Ema Senior Member

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    My apologies if this has already been posted.

    It's interesting all around but many of you know of my interest in adenosine/adenosine deaminase.

    Attached Files:

  15. JohnnyD

    JohnnyD Senior Member

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  16. aimossy

    aimossy Senior Member

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    Sorry @Ema Im only just up glad someone found it for you.
  17. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    Threads Merged
  18. Jonathan Edwards

    Jonathan Edwards Senior Member

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    For some reason I have not been getting flags for PR posts recently so I have not seen this until today. Thanks to those who picked it up. The results are complicated and I will need to go through the whole paper carefully. The markers for immature B cells are different from those used by others so there may be no direct comparison possible. Nevertheless, it will be important to see if there is a consistency here or not.
    NK17, alex3619, rosie26 and 1 other person like this.

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