The power of the mind - to reduce pain. Yes being hopeful reduces pain levels and now they know why - it increases the endorphin levels of the brain and when that happens your pain level drops. ME/CFS patients apparently experience less of the 'placebo effect' than normal (unfortunately). Perhaps we're less hopeful than others. This study suggests, though, that if you can build agood mindset then your pain should be reduced. I can't imagine that fatigue wouldn't be reduced as well. Interestingly a study released that year suggested that increased levels of CRH - a key factor in the HPA axis - reduces pain. (our HPA axis functioning is low). Could a release from preoccupying negative thoughts give a kick the HPA axis and increase endorphins?