Personally i think the definition for ME is very vague which is why its under the cfs umbrella. As august has said we need good research, we need biomarkers etc etc Just using symptoms is to vague, even the best ME definition is mostly symptoms. I dont see anything wrong with putting people into subsets as i think this will improve treatments. Its been mentioned before but like cancer it is put into subsets although the word subsets isnt used, there are many forms of cancer and i think its going to be the same with cfs/me with the common theme being immune dysfunction. Maybe they need to get serious with diagnosing cfs/me and use the nk function test and cd8 t cell function test as apart of a diagnoses, that would weed a few of the patients that have some other illness. We know these immune abnormalities, we should be asking why its not being used??