Hiya folks, Second post! This is some embarrassing newbie questions that I've tried to find answers to but all the information are so scattered... I know what brands richvank (god bless his soul) and fredd uses and I don't usually complain about scattered posts, that's just expected. But... what about everything else other than B12 and folate? What brands?? What about B-vit complexses, what NAC, TMG, DMG, glutathione, R-2-P, P5P... lecithin... eeeh-5-doh... (i love these emoticons, lol). ... so to actual questions. I want to clarify though that I've studied heartfixer and SNP's inside out. So feel free to use the methylation jargon liberally and no need to explain things as if I was a person who never read about this stuff. I've won my fight over brainfog and fatigue for most part so no worries there lol. 1. If I've understood right, lot of people seem to still use NAC and Glutanthione despite that they scavenge MB12/Metafolin? Is this because people tried them and felt better on them, or are there methylation SNP related reasons to do them? 2. What about THF, 5-M-THF, SAMe, SAH? What are the reasons to supplement those? Anecdotal/symptoms possibly improve or is it smart to take those on some SNP's? 3. What brand of B-vit complex you people in general have found to be best? Of course there are arguments for/against stuff like R-2-P but I would assume the general consensus is that active forms in B's are the best? 4. Is letichin etc a good substitute for TMG (if excess methyl issues) or have people found problems with them? What brand does people use for that? 5. How are people tolerating folinic acid?? I see fredd vehemently disliking them and heartfixer giving them a smaller role but some people here seem to do great on them. ! Blasmephy! !?! What sorcery is this?? lol (did i say that i love these emoticons?). Anyways, does that mean that I should as well order folinic acid, despite being a OK on SHMT? 6. Is Lithium still a work-in-progress stuff much like R2P, In terms of if it's essential? It seems Yasko and some people swear by it's detox/making b12 work - effect but is it certainly detox or is it the deficincies in folate etc? 7. I swear, I tried my best to seek answers for these but there is no general compilation of working brands for everything else than what is in fredd's and RVK's. I wonder why? Does that mean there are no conclusive definitive testing done on other brands, or is there just no interest to make a masterlist on those? And I apologize if my tone is accidentally accusative as I'm merely curious. I want to clarify though, I really appreciate any help and thanks in advance for patience and any help. Sorry for the jokes and emoticons...but i regret nothing LOL. Really though, the time and effort you do on your posts... I spent good chunk of yesterday just scrolling through the posts in astonishment... so many bright minds under the same roof, so much research! Wow!