The Nutrigenomics of Selenium

[Violeta]

I take Source Naturals Coenzymated B2 (FMN)
http://www.iherb.com/Source-Naturals-Coenzymated-B-2-Sublingual-60-Tablets/1036#p=1&oos=1&disc=0&lc=en-US&w=coenzymated b2&rc=52&sr=null&ic=3

Here is a good chart of how riboflavin is transported and metabolized into FMN and FAD (both are cofactors and reduced forms of riboflavin)

View attachment 12284

Here is a good brief explanation of FAD and FMN;
http://sandwalk.blogspot.com/2007/04/riboflavin-vitamin-b2-fmn-and-fad.html

If you are interested in the MTHFR gene you should look into riboflavin as well;
http://www.ncbi.nlm.nih.gov/books/NBK6145/

TXNRD2 is a thioredoxin Reducatse and helps with antioxidation in the mitocondria by recycling Thioredoixin. Thioredoixin is like glutathione.

View attachment 12285

When I first took FMN I had an immediate clarity and calmness that was so unusual it is indescribable. Now I notice it was a key to ending my IBS-D, fatigue, pain related to cartilage inflammation (costrocondritis). It also stops my heart palpitations 5 minutes after taking it. However, it is only part of my treatment. I found that taking FMN interacts with P5P, Zinc, and selenium.

Also, I found that since taking FMN I cannot take (nor do I need to) magnesium. When I do now, instead of it making me calm it makes me very up and anxious and keeps me awake instead of helping me drift off to sleep.

So interesting. And have you tried adding in Pantothenic acid, it looks like it's part of the picture, acetyl-CoA and enoyl-CoA?


Interesting that thioredoxin reductase has something to do with enoplasmic reticulum! Thanks for this thread!

http://www.febsletters.org/article/0014-5793(94)01386-F/abstract

 

[ppodhajski]

Just to give my two cents :


Selenium is important for Endoplasmic Reticulum stress control :

also Selenium is very important for proper protein folding :

However too much of it should be avoided :

Totally agree.

And our genetic differences are important because too much for one person might be too little for another. Or if you have high mercury levels since mercury binds to selenium.

http://darc.cms.udel.edu/SGSFR/Mercury selenium interactions and health implications.pdf
http://www.sciencedirect.com/science/article/pii/0041008X87902079

I found the Seleoprotein S SELS gene in 23andme
https://www.23andme.com/you/explorer/gene/?gene_name=sels

I am AG for rs4965373, no idea what that means but SNPs in that gene might point to a ned for higher selenium intake
http://www.ingentaconnect.com/content/ben/cppm/2012/00000010/00000003/art00005
The effects of Se supplementation on biomarkers showed significant variability based on age, BMI, health status and seleno-genotypes of SELS rs4965373, GPx1 rs1050450, and SEPP1 rs3877899. The data indicate that the benefits of supplementary Se vary significantly across a population, based on demographics, lifestyle, health conditions and seleno-genotypes

 

[ppodhajski]

So interesting. And have you tried adding in Pantothenic acid, it looks like it's part of the picture, acetyl-CoA and enoyl-CoA?


Interesting that thioredoxin reductase has something to do with enoplasmic reticulum! Thanks for this thread!

http://www.febsletters.org/article/0014-5793(94)01386-F/abstract

I did try Pantothenic acid, thought I would try it for high blood pressure before I got my genome. It had not effect one way or the other in any part of me. I do not see anything in me genetically that makes me think that I need it.

Plus, it is a cofactor that needs and additional component (ADP) and I do not take those, or only take them if I want to lower that component.
https://en.wikipedia.org/wiki/Cofactor_(biochemistry)

https://www.khanacademy.org/test-pr...d-function/v/cofactors-coenzymes-and-vitamins

 

[Violeta]

@mariovitali , they might like to see your computer program file for thioredoxin in this thread!

 

[Violeta]

I did try Pantothenic acid, thought I would try it for high blood pressure before I got my genome. It had not effect one way or the other in any part of me. I do not see anything in me genetically that makes me think that I need it.

Plus, it is a cofactor that needs and additional component (ADP) and I do not take those, or only take them if I want to lower that component.
https://en.wikipedia.org/wiki/Cofactor_(biochemistry)

https://www.khanacademy.org/test-pr...d-function/v/cofactors-coenzymes-and-vitamins

Ah, thanks for the video, I can't believe the amount of information I need to try to understand. This morning I almost called it quits on trying to learn anything new when I was reading somewhere. The video may help.