I've only just found out about the Nightingale definition of ME and it's diagnostic measures. Just wondering why it is not more widely recognised? I'm guessing it's because of the adoption of CFS; maybe it's time to bring it back to the fore and get the real ME researchers to at least consider it ? http://www.nightingale.ca/documents/Nightingale_ME_Definition_en.pdf The Nightingale Definition of Myalgic Encephalomyelitis (M.E.) Abstract M.E. is a clearly defined disease process. CFS by definition has always been a syndrome. It essential to define clearly Myalgic Encephalomyelitis. That is what the Nightingale definition of M.E. sets out to do. The definition is based upon two criteria: the excellent scientific work of respected physicians and scientists who investigated the various M.E. epidemics, and our modern scientific testing techniques and the knowledge resulting from examining thousands of M.E. patients using these techniques. Byron Marshall Hyde MD The Nightingale Research Foundation eta @Ben Howell @JaimeS input?