When I am at my worst, when I overdo it (like today: a hospital appointment, then a parents induction at my daughter's new school), I feel I have an increase in some kind of systemic inflammation in my body, the most noticable effect of that is noticable in my legs; in the muscles around my knees. I would almost say it is my knees, but I think it is more accurate to say it is the muscles surrounding, rather than the joint itself. So all my leg muscles, but much worse at the knee ends of those muscles. This is a symptom I've had for a while, but has been worse the last six months plus. My muscles there feel tired, fatigued, weak, almost switched "off," but more than that...they are giving off some kind of signal to my brain about what's going on there, but it's hard to articulate what that signal is. It's not quite pain, but tired/fatigued/weak etc. seem like inadequate terms. Does this match with anyone else? I am trying to figure out if this is the ME/CFS or something else, perhaps part of my colitis.