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Just found this while surfing the web. Wondering what you guys think about it, and whether it might work for treating POTS? It is my personal experience that anything that boosts ACh calms my heartrate.
http://www.townsendletter.com/FebMarch2013/milner0213.html
Beginning in 2008, Dr. Milner revisited his study of the autonomic nervous system (ANS) control of heart rate; he considered the actions of beta blockers which inhibit sympathetic ANS stimulation of the heart. He considered acetylcholine (ACh), the neurotransmitter of the parasympathetic ANS, and its action on heart rate inhibition. He then developed an approach for using oral supplements to augment ACh production and release.
MAP is indicated for any tachyarrhythmia, including sinus tachycardia, atrial tachycardia, supraventricular tachycardia, atrial fibrillation, atrial flutter, and accelerated ventricular rhythms, provided there are no contraindications with other aspects of treatment. MAP is also indicated for ectopic arrhythmias such as premature atrial contractions (PACs) and premature ventricular contractions (PVCs).
The MAP dosing works in a three-stage dose escalation (Table 1). At stage 1 we deliver 500 mg of pantethine and 2000 mg of choline per day. Due to the very short half-life of ACh we are able to tell within one week whether this dose is adequate. If the patient achieves complete symptomatic or objective improvement over the course of the first week then the MAP is maintained at stage 1; if not, we escalate to stage 2. Stage 2 dosing is 1000 mg of pantethine and 4000 mg of choline; after one week we reassess. If resolution of symptoms or objective findings is complete or near complete we stop at stage 2, otherwise we escalate to stage 3. Stage 3 dosing is 1500 mg of pantethine and 6000 mg of choline. Reassessment is made after one week in the same manner as previous stages. It is rare that more than 1500 mg of pantethine will demonstrate further benefit, though we have had patients who needed to escalate the initial dose of choline up to 10 grams before coming under rhythm control.
http://www.townsendletter.com/FebMarch2013/milner0213.html