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The IiME/UCL UK Rituximab Trial inital target has been reached

Discussion in 'Rituximab: News and Research' started by deleder2k, Aug 8, 2014.

  1. deleder2k

    deleder2k Senior Member

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    Great news from the United Kingdom today:

    Great to see a trial is soon underway in both U.K and Norway.
     
    Marky90, trails, merylg and 23 others like this.
  2. Esther12

    Esther12 Senior Member

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    Thanks to all who contributed to this.
     
    trails, Bob, rosie26 and 2 others like this.
  3. DanME

    DanME Senior Member

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    Fantastic news and congratulations to the UK team!!
     
    Marky90, Bob, rosie26 and 2 others like this.
  4. Min

    Min Guest

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    10574262_10152282619332507_3034876034836565418_n.jpeg
     
    Bob, catly, NK17 and 6 others like this.
  5. justy

    justy Senior Member

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    Such fantastic news! Let's hope the results are everything we hope for and that M.E patients will soon be looking forward to not just having a treatment available, and an explanation for our illness, but being treated with respect and concern by the medical profession.

    Bring it on!
     
    merylg, Bob, Cheshire and 8 others like this.
  6. barbc56

    barbc56 Senior Member

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    Wonderful!!! Thanks for posting this.
    Barb
     
    Bob, rosie26 and Min like this.
  7. alex3619

    alex3619 Senior Member

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    Regardless of the outcome of the trials, this is another milestone for our community. If some scientific study is important to us then we can make it happen. Government and institution funding committees be damned.
     
    jimells, merylg, ahimsa and 10 others like this.
  8. rosie26

    rosie26 Senior Member

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    It is great. Rituximab has been so important to us and has made other researchers take note too I think.
     
    Last edited: Aug 9, 2014
    merylg, Bob, deleder2k and 1 other person like this.
  9. daisybell

    daisybell Senior Member

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    :balloons::balloons::balloons::)
     
    Bob and deleder2k like this.
  10. NK17

    NK17 Senior Member

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    This is music to my ears ;). Now I'd like to see things moving here in the US too, but I'm afraid we'll have to wait a few years to get both the Norwegian and British studies' results analyzed and published, before the FDA will start to seriously look into this.
     
    catly and Min like this.
  11. leokitten

    leokitten Senior Member

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    Why can I not find the IiME UCL Rituximab trial on clinicaltrials.gov? The Norwegian trials are easy to find there.
     
  12. Sasha

    Sasha Fine, thank you

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    The trial design hasn't been finalised yet - there's some important preliminary work that needs doing first.

    http://www.ukrituximabtrial.org/Rituximab news-Aug14 02.htm
     
  13. BurnA

    BurnA

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    Does anyone know when the next update is due on this trial ? Last one seems to be Aug 14.

    Also, any potential start date / end date for the clinical trial itself ?

    I find sometimes just knowing the schedule brings me a calmness.

    Is the aim of the preliminary study to identify which subset of patinets are likely rituximab responders ? If so would it be possible then for a CFS patient to get a blood test to know if they are a repsonder or not ?
    Thanks
     
    Scarecrow likes this.
  14. Sasha

    Sasha Fine, thank you

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    No recent updates.

    Yes, that's correct.

    We hope so! But I'd be surprised if it was a test that you could get from your GP - I'd think it was more the sort of test that researchers use in the lab.

    Is that the case, @Jonathan Edwards?
     
    Scarecrow likes this.
  15. BurnA

    BurnA

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    Would be nice to get the experts opinion on this and how likely a possibility this is within the next year or so ?

    Thanks
     
    Sasha likes this.
  16. Sasha

    Sasha Fine, thank you

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    I agree, it's always good to get updates on a long-burn thing like this when we're all waiting in eager anticipation, even if it's just "we're not there yet" or "the next steps are X, Y, Z."

    Why not email IiME and suggest it?
     
  17. Jonathan Edwards

    Jonathan Edwards Board Member

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    I don't think there is anything particular to update at present. Tests for responders are going to have to be validated by trials as we move forward so there is nothing to be measured just now.
     
    Sasha likes this.
  18. BurnA

    BurnA

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    Thanks a lot..
    I appreciate from a scientific point of view there may not be anything to update but even from a scheduling point of view is there anything to say ? i.e. proposed end date of current study, next steps, proposed start of further trials etc ? It would be nice to know, even if its a best guess.

    When you say tests need to be validated by trials - would that be the clinical trial or a further study as part of existing preliminary study ? Will it possible to begin such trials without delay or when would be likely ?

    Could you estimate when it might be likely that a CFS patient could get there blood tested to determine if they are a responder or not ?

    Also, for the non responders, is there any progess on the horizon for them ?

    Thanks, - I realise I have asked a lot of questions so any info at all would be very reassuring.
     
  19. Jonathan Edwards

    Jonathan Edwards Board Member

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    I think the thing that should reassure people most is that we now have several high quality research groups in Europe, North America and Australia all trying to pin down the immunological side of the condition. What is particularly important is that they all want to share data and compare notes and feel confident that they are getting real answers. I gather from IiME that some new grants have been awarded in the US which is also good news. Researchers get together regularly and weigh up the pros and cons of moving forward this way or that way, constantly rethinking the arguments to make sure resources are used most effectively. It has taken longer than we initially expected to get a UK trial up and running (and I cannot say anything more specific) but the Norwegian phase 3 study has taken off and momentum is building.

    I am sorry not to be able to say anything more specific but trial design is a very fragile thing and giving out information constantly can get in the way of having the best options.
     
    leokitten, ukxmrv, Marky90 and 10 others like this.
  20. BurnA

    BurnA

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    Thanks again and I understand not being able to give out specific information. ( dates would be nice though :) )

    Regarding the immunological side of the condition, I read in another thread you believe that may represent 60% of patients. Can you elaborate on how you came to that figure ?
    Also, is there any attribute that can be linked to the immunological side of the condition ie specific symptoms, onset, duration, severity etc. ( From the phase 2 norwegian study there doesn't appear to be but just wondering if anyone has looked at or might look at this.)
    For the non immunological side - is there any work on this to understand it better ? Are there two different diseases at play here ?
    Thanks very much yet again!
     

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