The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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The Histamine Gene rs10156191

Discussion in 'Mast Cell Disorders/Mastocytosis' started by drob31, Apr 12, 2015.

  1. drob31

    drob31 Senior Member

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  2. Gondwanaland

    Gondwanaland Senior Member

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    My husband and I are respectively CT and CC.

    But how about the DAO SNPs? We both are +/+ for one of them.
     
  3. drob31

    drob31 Senior Member

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    rs10156191 Histamine/DAO is DAO I think.
     
  4. Gondwanaland

    Gondwanaland Senior Member

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    23andMe says it is ABP1.
     
  5. drob31

    drob31 Senior Member

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  6. Gingergrrl

    Gingergrrl Senior Member

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    How do you find this histamine gene on 23andMe through Genetic Genie? Does it have a different name? Sorry for another dumb question!
     
  7. drob31

    drob31 Senior Member

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    Click on Gondwanaland's link, and log in to 23andme.com, and it will show you the SNP's for the histamine gene.
     
  8. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    I'm CC. And on the link from @Gondwanaland, I have 11, of which 9 are homozygous. Is this the source of my histamine issues??
     
  9. Gingergrrl

    Gingergrrl Senior Member

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    Can you see it on the Genetic Genie print out? I have never logged into 23andMe and not sure what you do?
     
  10. Gondwanaland

    Gondwanaland Senior Member

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    Apparently not - I think +/+ MAO-A is enough reason ;)
    Nope.
    Username, password, raw data, then paste rs10156191 into SNP box or ABP1 into gene box.
    Easier if just clicking the link on post #4 and logging in from there.
     
  11. Valentijn

    Valentijn Senior Member

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    rs10156191 TT is pretty common: about 10% of people have that genotype, going up to 40% in some ethnic groups. It's a bit interesting, because according to the research at http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2011.02548.x/full it's associated with down-regulation of the gene, but not associated with histamine intolerance at all.

    It would seem to suggest that the down-regulation of the AOC1 gene caused by rs10156191 TT isn't sufficient to cause any problems. It's not too uncommon for that to happen on various genes.
     
    ukxmrv likes this.
  12. drob31

    drob31 Senior Member

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    Thanks val. Do you base the SNP mainly on prevalence? I'm just wondering because I'm working with someone who is basing their research on the correlation with the SNP's in literature (pub med, etc), and not prevalence.
     
  13. drob31

    drob31 Senior Member

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    9 out 11 seems like quite a bit.
     
  14. Valentijn

    Valentijn Senior Member

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    No, the research is more important. But it's unlikely a genotype for a SNP is causing much mayhem when it's present in 10% of the world's population :p
     
  15. Valentijn

    Valentijn Senior Member

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    Being homozygous or heterozygous doesn't mean anything at all, in itself. You have to look them up to see if there's research saying if they cause a problem or not.
     
  16. Sidereal

    Sidereal Senior Member

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    CC here yet major histamine problems.
     
  17. brenda

    brenda Senior Member

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    CC and major histamine problems.
     
  18. drob31

    drob31 Senior Member

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    How about for the other 10 SNP's of ABP1?
     
  19. drob31

    drob31 Senior Member

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  20. brenda

    brenda Senior Member

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    UK
    CC
    CC
    CC
    GG
    CT
    AG
    CT
    GG
    CG
    AA
    CC
     

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