JPV
ɹǝqɯǝɯ ɹoıuǝs
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However, Mark London does not agree with Bennett that guaifenesin is just placebo, and London thinks guaifenesin may be helping fibromyalgia patients via other mechanisms, such as through its ability to relax skeletal muscles, and/or via its analgesic effects.
I saw Paul St. Amand about 15 years ago and tried the treatment, under his supervision, for several months. It didn't really work for me though it seems to be helpful for some people.
I agree that his theory about phosphate excretion is most likely wrong. Guaifenesin seems to be an NMDA antagonist, although probably a weak one, and I'm guessing this is probably the mechanism behind why it seems to work for some people...
Anticonvulsant Effect of Guaifenesin against Pentylenetetrazol-Induced Seizure in Mice
Background: There have been some reports about the possible N-methyl-D-aspartate (NMDA) antagonist activity of Guaifenesin. As drugs with a similar structure to Guaifenesin (i.e. Felbamate) and those with NMDA antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether Guaifenesin has an anticonvulsant effect in an animal model of seizure.
Conclusion: These results suggest that Guaifenesin possesses muscle relaxant and anticonvulsant properties and may have a potential clinical use in absence seizure.
I feel like I get better results using Magnesium Threonate and Magnesium Oil in regards to controlling NMDA activity...
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