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The Farnesoid X Receptor: Good for BAD (Bile Acid Diarrhea)

Discussion in 'Other Health News and Research' started by nanonug, May 3, 2018.

  1. nanonug

    nanonug Senior Member

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    Virginia, USA
    COMMENT: Bile acid diarrhea is something that for whatever reason I've had for a long time. I intend to start very soon an experiment with a natural FXR agonist to see what happens.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247348/

    Abstract

    Diarrhea is a feature of several chronic intestinal disorders that are associated with increased delivery of bile acids into the colon. Although the prevalence of bile acid diarrhea is high, affecting approximately 1% of the adult population, current therapies often are unsatisfactory. By virtue of its capacity to inhibit colonic epithelial fluid secretion and to down-regulate hepatic bile acid synthesis through induction of the ileal fibroblast growth factor 19 release, the nuclear bile acid receptor, farnesoid X receptor, represents a promising target for the development of new therapeutic approaches. Here, we review our current understanding of the pathophysiology of bile acid diarrhea and the current evidence supporting a role for farnesoid X receptor agonists in treatment of the disease.
     

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