For the record: My biological mother, who I did not grow up with has been diagnosed with M.E. Her neice (my maternal cousin) has been diagnosed with M.E. I have M.E. My eldest daughter was sick at 15 and bedbound, at the same time that I had a severe relapse. She is much better now (age 21) but has poor stamina and other issues which have never resolved. Her onset, with slow but gradual recovery with no treatment in early 20's is very similar to my initial event 20 years ago. However I worry about her health as I have had a sevre relapse 6 years ago that I am still recovering from, after man y years of only being mildly affected. She seems to be going down a similar path. My youngest son is a worry also as he often feels very worn out and tired, especially from mental exertion - he finds piano lessons and practise exhausting at times - although he has no other symptoms currently. My eldest daughter and youngest son can both bend their thumbs back down to their wrists, and although I have never heard of this being an issue for people with EDS etc they also have both broken bones from minor falls. My daughter has broken one of her arms in four places on four separate occasions. My youngest son fell in a park last year and snapped two bones in his fore arm and had to have a bog operation to repair it, which had a long recovery time. My other two children who look very alike have no problems, no hypermobility and no broken bones ever.