Hunting down the cause of ME/CFS & other challenging disorders - Lipkin in London
In a talk to patients in London on 3rd September, Dr. W. Ian Lipkin described the extraordinary lengths he and his team are prepared to go to in order to track down the source of an illness, with examples ranging from autism to the strange case of Kawasaki disease.
Discuss the article on the Forums.

The enemy within: dormant retroviruses awaken

Discussion in 'Other Health News and Research' started by Rosemary, May 7, 2010.

  1. Rosemary

    Rosemary Senior Member

    Messages:
    193
    Likes:
    0
    The enemy within: dormant retroviruses awaken
    http://www.nature.com/nm/journal/v16/n5/full/nm0510-517.html

    Mammalian genomes harbor regulatory elements from ancient retroviral infections. These retroviral remnants are normally silenced by DNA methylation—but this can change. Reactivation of one such element triggers the expression of a nearby oncogene during the development of Hodgkin's lymphoma (571–579).

    http://www.nature.com/nm/journal/v16/n5/full/nm.2129.html
    Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

    Over 100 million years ago, retroviruses began their assault on mammals by infiltrating the mammalian genome. In defense, mammals developed the ability to recognize and silence transcription from these integrated retroviruses.
     
  2. awol

    awol *****

    Messages:
    417
    Likes:
    0
    Yes, I've found this interesting too. Even without XMRV, the retrovirus theory is worth looking into because herpes viruses are known to be able to reactivate endogenous retroviruses, and endogenous retroviruses can let loose dormant herpes viruses...hmm...feedback loop?
     

See more popular forum discussions.

Share This Page