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The enemy within: dormant retroviruses awaken

Discussion in 'Other Health News and Research' started by Rosemary, May 7, 2010.

  1. Rosemary

    Rosemary Senior Member

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    The enemy within: dormant retroviruses awaken
    http://www.nature.com/nm/journal/v16/n5/full/nm0510-517.html

    Mammalian genomes harbor regulatory elements from ancient retroviral infections. These retroviral remnants are normally silenced by DNA methylation—but this can change. Reactivation of one such element triggers the expression of a nearby oncogene during the development of Hodgkin's lymphoma (571–579).

    http://www.nature.com/nm/journal/v16/n5/full/nm.2129.html
    Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

    Over 100 million years ago, retroviruses began their assault on mammals by infiltrating the mammalian genome. In defense, mammals developed the ability to recognize and silence transcription from these integrated retroviruses.
     
  2. awol

    awol

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    Yes, I've found this interesting too. Even without XMRV, the retrovirus theory is worth looking into because herpes viruses are known to be able to reactivate endogenous retroviruses, and endogenous retroviruses can let loose dormant herpes viruses...hmm...feedback loop?
     

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