I could get nuts over it, because it is so obvious. Still, nothing is moving. MBL deficiency is the most common immune defect. I do know, from various boards, that its prevalence among CFS patients is high above the average. Of course, most of them have never been tested for it A simple blood test for MBL costs around 30 Euros (might be somewhat more expensive in the U.S.). Running the test on a sample of 100 patients would thus cost a few thousand dollars / euros. What is to be gained? If there is an correlation between the two (and I have little doubts there is), there would be a crystal clear physiological cause for CFS. For a large group of CFS patients there would also be a ready treatment, or should I rather say cure available. Human MBL can both be gained from plasma as well as a recombinant product. What's more: MBL is known to be a relevant contributing factor in chronic herpes infections: http://www.biochemsoctrans.cn/bst/031/0768/0310768.pdf Up to the present day however, it seems there has not even made an attempt to link the most frequent immune defect to a disease with 17 mio sufferers world wide. This is ridicolous! There must be a patient organization or a specialist willing and able to run this simple research.