Low glutathione is another common factor that all of these diseases share; just like low iron, zinc, vitamin D, B12, dopamine, phenylalanine, adrenaline, noradrenaline, high homcysteine, dysautonomia, spinal cord changes, elevated tumor necrosis factor and abnormal calcium metabolism. They also share the same symptoms due to the lack of the same hormones, neurotransmitters, lack of nutrients and conditions, such as the abnormal calcium metabolism. All of the scientific findings, including every symptom, every missing nutrient, and every dysruption that results, such as elevated tumor necrosis factor and dysautonomia can be traced directly back to one thing. And only one thing. The lack of proteases. Science has proven this. The evidence is overwhelming. Low glutathione does not explain the lack of hormones and neurotransmitters. It does not explain dysautonmia or the lack of vitamin D. The same thing that explains low glutathione explains low vitamin D and the lack of hormones and neurotransmitters. I believe I have shown conclusively by using scientific data that these diseases originate with the lack of proteases. So when does a hypotheses that is based on proven science become truth? The questions you ask, such as how SAMe and folates compare to lack of glutathione, have already been answered. Glutathione is also low in MS. Here is one study that addresses B12, folate and homocysteine in MS. You can find additional studies in all of the autoimmune diseases. http://www.ncbi.nlm.nih.gov/pubmed/19153046 Vitamin B12 acts as a coenzyme in the transformation of homocysteine to methionine. This reaction is essential to make S-adenosylmethionine (SAMe). If all of these diseases lack B12, then they would of course not be able to produce SAMe. This is science and logic. You don't have to draw blood to prove this. Although you certainly could. These diseases have been named after their primary symptoms, i.e., lupus "marks of a wolf", rosacea "flushed blood vessels", myasthenia gravis "heavy muscles". I think they should be named after their cause, "Pancreatic Enzyme Deficiency Disease " (PEDD). The lack of these proteases explains the most definitive evidence we have in ME/CFS-The spinal tap studies. Suzanne Vernon, the scientific director of the Chronic Fatigue and Immune Dysfunction Syndrome Association of America stated, "You can't dispute these biological findings." The No. 1 finding was a protease imbalance. All of the other findings are also directly related to this lack of protease. I don't expect that most researchers, pharmaceutical executives, or even medical professionals will acknowledge this evidence. There would be no monetary benefit. This information would devastate the economy of the richest most powerful people in the world. It would put untold numbers of researchers and medical personnel out of work. Their jobs and their livelihoods depend on not finding the answer. The evidence will be ignored, but it cannot be denied. Rich,I think our research is compatible. We have much common ground. And if the people that are supposed to be helping are not, then we most certainly should. I don't expect autonomic agreement. I know you will weigh the facts and give thoughtful consideration to the evidence presented. I have talked a great deal about the immune system and its involvement in these diseases. Science has shown that the immune system is targeting abnormal peptides. It is also targeting unbroken down DNA and proteins, such as in the lupus NETs. The third component is elevated tumor necrosis factor (TNF). TNF is a cytokine. It is a normal necessary part of the immune system. I previously posted a study entitled: "Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome.." The immune system is not broken. It is just not being regulated properly and it is just doing it's job by targeting abnormal proteins. What is responsible in the body for regulating TNF? As the following study states, " proteases are key regulators of the inflammtory response." It goes on to state, "proteases specifically process and release CYTOKINES." Is this a hypothesis? No, it is fact. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440796/ Speaking of hypothesis and fact, I haven't posted anything concerning the disease process that isn't fact. I hope this information helps you question what you have been told. I hope it brings you closer to the answers you have searched for. The moderators and I have decided today that this thread is off-topic. This is my last post on this thread. I have publishing deadlines I need to attend to, but I hope when I am able to start posting again under a new thread.