Annesse, your personal story of recovery and your hypothesis, albeit largely over my head, sounds very interesting. I hope you will continue to post. I don't think anyone was telling you not to, just the thread title was different to the main content of this thread. You could even start a new thread devoted to your work. I think there are many of us that would like to hear more However, there is one point you made that I don't quite understand. You mention earlier in this thread that the fatigue between MS and ME is in your opinion the same. You provide a link on the nature of fatigue in MS. My understanding is there is a difference. Mainly fatigue in m.e is actually often not fatigue per se but post exertional malaise or the more recent phrase post exertional neuro immune exhaustion. Exertion makes us worse. My understanding is people with ms do not have this pem. Until their mobility becomes too restrictive they can exercise/undertake activity (say go out for a coffee with a friend) without an exacerbation of symptoms. They may feel fatigued but do not have to so carefully keep within their energy limits if they want to avoid a symptom flare. Also I thought I read somewhere once (i may be wrong) that if people with ms are able to be as active as they can, it can help their fatigue. This is the deadly opposite in m.e. Have you any thoughts on this? Also re Enid mentioning a trigger. My mum came down with m.e the same year as me. She was 52 I was 27. She was perfectly healthy until then. Does a trigger fit into your hypothesis? If so, how? I had some vitamin testing done a few years back. I came up as low in zinc and magnesium and very low in B vitamins 1, 2 and 6 which I think fits in with what you say you found. I'd also be interested in your thoughts on LDn Many thanks.