The Concept of Fatigue in Multiple Sclerosis Journal of Neuroscience Nursing While this article at Medscape (note: registration required -- and well worth the hassle) is specifically about Multiple Sclerosis, I found it to be interesting reading in terms of comparing and contrasting with ME/CFS as the two illnesses are so very similar. To begin with is a definition of "fatigue": Having a standard definition like this for fatigue, or even a standard list of types of fatigue, would be particularly helpful in studying it across illnesses. It was interesting to note that approaches to the treatment of fatigue in MS are very similar to ME/CFS, including energy conservation. I had no idea that anybody besides Lenny Jason had really studied energy conservation much. Just as with ME/CFS, clinicians trying to assess fatigue in MS have a difficult time as well: Seems as if just about everybody finds questionnaires to be problematic. Unless you're Trudie Chalder... ;-) Speaking of Ms. Chalder, the last observation I had was the ability of the authors to discuss pyscho-neurological symptoms like depression without an assumption that the fatigue itself is psychogenic in origin or a long disclaimer about how it really is a result an underlying biomedical condition. How I cannot wait for the day when the same is true with ME/CFS. While there isn't any sort of epiphany here regarding ME/CFS, I think we can learn a great deal by reading as widely as possible about how other disease communities are dealing with a similar issue. Articles like this show us how a journal like Fatigue, mentioned a few months back on Co-Cure, could be particularly useful for ME/CFS patients, as well as other diseases, without trivializing ME/CFS as just "fatigue."