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The Concealed Causes of "Thyroid Resistance"

Discussion in 'Thyroid Dysfunction' started by drob31, Sep 24, 2014.

  1. drob31

    drob31 Senior Member

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    Just to update this thread, I'm pretty sure my "hypothyroidism" is caused by high cortisol. Not only does high cortisol make the cells resistance to thyroid hormones. It makes the cells resistance to every hormone, including cortisol. This may be why high cortisol can feel like low cortisol.
     
    Little Bluestem likes this.
  2. picante

    picante Senior Member

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    Chiming in with my own thyroid "mysteries". @ahmo, I can't believe there is someone else in the world who bought John Lowe's big, fat textbook. I used to haul it along to the doctor's office, :lol: hoping they would have time to take a look.

    My metabolism crashed when I had EBV, but it took 11 years before I got the "hypothyroid" diagnosis, due to lack of health insurance and lack of "abnormal" TSH levels. Being skinny didn't help.

    With a TSH result of 7.5, my ND put me on NDT and it had no effect. Still plagued with hypo symptoms, I asked for antibody tests: TPO was over 500. My ND said "take selenium"!

    Eventually I ran across Stop the Thyroid Madness (the book -- this was before the website existed), so asked for RT3 and FT3 tests, then calculated my ratio, which was 14. At the time, the T3 forum on Yahoo was saying it should be 20. So I went on Cytomel. The antibodies came down to 80-95.

    Cytomel reduced my myofascial pain to a tolerable level (my arms & feet could function again!) and gave me a bit of energy. It also resolved my gut problem, which was that every time I ate, I would get a rather painful bloat going while eating and felt like I might explode. (Unable to eat much, I had become officially "gaunt" at 108 lbs.)

    I've been hassled by a number of mainstream docs about having "high" T3 levels. I always ask them whether the labs are ever going to establish a range for people taking T3.

    Meanwhile I read Dr. Abraham and Dr. Brownstein on iodine. A couple searches online told me they were right about iodine being OK for Hashi's patients as long as we take selenium, too. I started taking Lugol's. I didn't know what it was doing, really, until I stopped it for a while. It had gotten me to menopause (finally) at age 56. When I stopped Lugol's, I started spotting. When I went back on it, just after I turned 57, I stopped. :balloons:

    Next post: T3 & arthritis, plus wild temperature fluctuations on methylB12 last summer. Enough for now. Thanks for reading, dear friends.
     
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  3. ahmo

    ahmo Senior Member

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    Ha ha. I left the book with the one specialist in Fibro that I saw, who knew less than me. Later I retrieved it, and gave it to my GP once I uncovered the gluten issue.:D

    I might ask for antibody tests from my GP next week..then again, I'm doing ok by treating by symptoms...:whistle:
     
    Last edited: Jan 26, 2015
    picante and Gondwanaland like this.
  4. Gondwanaland

    Gondwanaland Senior Member

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    I wonder what changes from being high in anti-thyroglobulin antibodies rather than anti-TPO?
     
  5. Unim

    Unim

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    Reading through some of Andy Cutler's stuff recently, I found he said that getting NAET to 'clear' calcium has helped some people respond better to physiological doses of thyroid. http://onibasu.com/archives/amc/1898.html

    I don't actually know what NAET is, other than I've heard it's expensive and apparently not all practitioners are effective. Seems kind of wacky, but who knows...
     
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  6. picante

    picante Senior Member

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    I've always wondered, too, izzy.
     
  7. ahmo

    ahmo Senior Member

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    @Unim My only knowledge of NAET is from a member of a GAPS forum, who's found it effective for many things, and recommends it often, especially for kids. well, it's mostly a forum of mums with kids. Interesting that Cutler's found it effective.
     
  8. Sporty

    Sporty Senior Member

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    I think I'm thyroid resistant too. I've been taking thyroid meds for years, but they never seem to work for me....
     
  9. picante

    picante Senior Member

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    Is your calcitriol (1,25 D) high? I've been looking into this, because mine is. I found this:

    http://mpkb.org/home/pathogenesis/vitamind/metabolism#case_in_pointthyroid_receptor
     
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  10. Sporty

    Sporty Senior Member

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    Essex, UK
  11. picante

    picante Senior Member

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    Yes, that's 25 OH D. Calcitriol can be high for many of us, while 25-OH-D is low or mid-range.
     
  12. xks201

    xks201 Senior Member

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    And why shouldn't one take b vitamins with thyroid?
     
  13. ahmo

    ahmo Senior Member

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    I don't know the answer to this. It's something I learned from one or more of the presenters of last year's Thyroid Summit, or Hashimoto's Summit.
     
  14. xks201

    xks201 Senior Member

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    I don't believe anything unless I see evidence. But I would be interested to know his reasoning.
     
  15. picante

    picante Senior Member

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    So would I, and it's hard to find that info with a Google search (I tried).

    The problem with waiting for evidence is you'll wait forever:
    • Is it studies you're wanting? Most scientific studies are highly biased toward the wrong questions for our purposes. And they don't provide a very complete picture -- just itty-bitty pieces of a gazillion-piece jigsaw puzzle. A few are useful.
    • Is it evidence from other people's experience you're wanting? I find it helpful. Here on PR I keep seeing that people's response to supplements is variable, and then we discuss what might be influencing those responses.
    • Is it evidence from your own body you're wanting? It can be hard to interpret, but it's valid. Personal experimentation gives me more clues than anything else.
     
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  16. drob31

    drob31 Senior Member

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    I'm not sure about anything anymore, I'm sort of back to the drawing board.

    One thing that has been a HUGE help is pregnenolone, so maybe that's a clue. I started out wiIh 50 mg and it helped a ton with working memory, word recall and libido, however it didn't fix everything. At 50 mg, I felt like it was too low, so I went to 100 mg and that was a pretty good dose. I've been on that for 5 weeks now.

    My last saliva test showed a more normal cortisol rythm, but I still feel it's very sensitive and could change from day to day.

    I still have weird temperature sensitivities, cold fingers usually in morning, feeling warmer at night. I have diffuse hair shedding. The folicles get extremely itchy and fall out where the itchy feeling occurs. My energy levels are so lower but better overall. I have much more focus and mental ability with pregnenolone.

    I did test positive for the cyrex autoimmune pannel for antiphospholipid anitbodies, but subsequent test showed them to be negative, so it's either a false negative, or perhaps a red herring. I have red that pregnenolone helps people with lupus and similar autoimmune issues. But it would also help with "Adrenal issues." I've been taking 40 mcg of PQQ for the last 6 weeks as well, and 1-2 grams of tumeric a day.
     
    picante likes this.
  17. Gondwanaland

    Gondwanaland Senior Member

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    I started preg yesterday at 1.25mg based on Ray Sahelian's advice.
    My toxic FM and gouty (?) arthritis subsided slightly, but at the same time I started Boswellia at higher doses which is clearly helping with pain.

    Tomorrow will take 2.5 mg preg, and am trying to decide if I will take it continuously or a few days on /off.
    http://www.raysahelian.com/pregnenolone.html

    In addition to adrenal support, I need to increase all hormones. Serum estradiol came out indetectable.
     
    picante likes this.
  18. picante

    picante Senior Member

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    @Gondwanaland, I just ran across this on Chris Kresser's website:

    Is this true? If so, I'll bet your estrogen levels are not always low!
     
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  19. Gondwanaland

    Gondwanaland Senior Member

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    They have probably been quite high some times, but now everything is messed up, at least since 2013 when I started the progesterone cream that suppressed both my estrogen and testosterone.
     
  20. drob31

    drob31 Senior Member

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    Pregnenelone at a dose of 100 mg has increased my estradiol, however I have been doing allot better lately with every symptom.

    I added DIM and my libido immediately shot back up again. It seems that you must dial pregnenolone in.
     
    Gondwanaland likes this.

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